{"id":"W4293755987","doi":"10.1158/1078-0432.ccr-22-0931","title":"Detection of <i>BRCA1</i> , <i>BRCA2</i> , and <i>ATM</i> Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; BC Cancer Agency","funders":"MSD K.K.; Merck Sharp and Dohme; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Cancer; Prostate cancer; Concordance; Prostate; Oncology; Internal medicine; Cancer research; Frameshift mutation; Pathology; Gene; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005301613,0.0002085016,0.0002133031,0.000350665,0.0001511117,0.0002939611,0.0002206831,0.000202691,0.0006359684],"category_scores_gemma":[0.001042666,0.0001499041,0.0001415448,0.0001830528,0.000227715,0.0001267912,0.0002356071,0.0002068609,0.0001080751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511411,"about_ca_system_score_gemma":0.0002344761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001207146,"about_ca_topic_score_gemma":0.0020122,"domain_scores_codex":[0.9996957,0.00008901555,0.00002482589,0.00009213403,0.00006915977,0.00002935432],"domain_scores_gemma":[0.9995994,0.0001060506,0.0001279736,0.00003348078,0.00004737062,0.00008574146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002181268,0.000127501,0.9582235,0.00004940184,0.00005133747,0.0001988418,0.0001290968,0.0003513807,0.02438138,0.00003879356,0.0001861061,0.01408134],"study_design_scores_gemma":[0.0001753592,0.003789119,0.9769208,0.00002008548,0.0001216006,0.002489761,0.0001334213,0.001343473,0.01429313,0.00005932436,0.0006447581,0.000009103014],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993317,0.0001834095,0.0001242824,0.00001075517,0.000001130859,0.00001096876,0.00007374886,0.000008050115,0.0002559836],"genre_scores_gemma":[0.9995289,0.00003619377,0.0002216192,0.00002433935,0.000002106292,0.000004592218,0.0001302385,0.000001384499,0.00005058568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207146,"threshold_uncertainty_score":0.002803802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07236811365894866,"score_gpt":0.4278130276015846,"score_spread":0.355444913942636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}