{"id":"W4293755987","doi":"10.1158/1078-0432.ccr-22-0931","title":"Detection of <i>BRCA1</i> , <i>BRCA2</i> , and <i>ATM</i> Alterations in Matched Tumor Tissue and Circulating Tumor DNA in Patients with Prostate Cancer Screened in PROfound","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; BC Cancer Agency","funders":"MSD K.K.; Merck Sharp and Dohme; Medical Research Council; National Institute for Health and Care Research","keywords":"Medicine; Cancer; Prostate cancer; Concordance; Prostate; Oncology; Internal medicine; Cancer research; Frameshift mutation; Pathology; Gene; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00237224,0.0001811207,0.0005834757,0.0004883098,0.0001871502,0.00003794226,0.0001193808,0.00006008169,0.00007832194],"category_scores_gemma":[0.0002279507,0.0001509175,0.00003176592,0.001474865,0.0004602154,0.0001771753,0.0002796753,0.00127539,9.03971e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006759464,"about_ca_system_score_gemma":0.0009133814,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006675632,"about_ca_topic_score_gemma":0.01009156,"domain_scores_codex":[0.9963249,0.0006419815,0.0007913968,0.0006869623,0.0009107217,0.0006440112],"domain_scores_gemma":[0.9986855,0.000422566,0.0001380403,0.0002701688,0.0002757826,0.00020789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007922601,0.0007443936,0.97,0.00037355,0.00003637042,0.0001302128,0.0008696145,0.00008622089,0.004610151,0.00000924159,0.00002896782,0.0151887],"study_design_scores_gemma":[0.01687388,0.00249278,0.9738167,0.000588354,0.00002048271,0.000007430845,0.0007363914,0.0006043829,0.004190545,0.000124114,0.0003569873,0.0001879508],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932739,0.002163052,0.00000143101,0.00133539,0.000067559,0.002915365,0.00009550682,0.00001300518,0.0001348308],"genre_scores_gemma":[0.9968532,0.000551094,0.0000572635,0.0001814601,0.000058959,0.002001251,0.00003652769,0.00004011224,0.0002201665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01500075,"threshold_uncertainty_score":0.999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07236811365894866,"score_gpt":0.4278130276015846,"score_spread":0.355444913942636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}