{"id":"W4293768928","doi":"10.2147/opth.s376199","title":"Early Canadian Real-World Experience with Brolucizumab in Anti-Vascular Endothelial Growth Factor-Experienced Patients with Neovascular Age-Related Macular Degeneration: A Retrospective Chart Review","year":2022,"lang":"en","type":"article","venue":"Clinical ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Dalhousie University; Barrie Urology Group; Centre Intégré de Santé et de Services Sociaux des Laurentides; NOSM University; Sunnybrook Health Science Centre; Centre Hospitalier Universitaire de Sherbrooke","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Macular degeneration; Ophthalmology; Visual acuity; Ranibizumab; Retrospective cohort study; Confidence interval; Branch retinal vein occlusion; Retinal vasculitis; Macular edema; Aflibercept; Retinal; Vasculitis; Surgery; Internal medicine; Bevacizumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002627908,0.0003592589,0.001097392,0.0002175194,0.0002634693,0.00002071733,0.0002554621,0.000120132,0.001992391],"category_scores_gemma":[0.0002336949,0.0002736957,0.0003192107,0.000899683,0.0003863577,0.0001200585,0.00008965292,0.0005817891,0.00002427918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005408802,"about_ca_system_score_gemma":0.0005439516,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02161305,"about_ca_topic_score_gemma":0.001129306,"domain_scores_codex":[0.9964004,0.0005154496,0.000821022,0.0009842351,0.000667099,0.0006118612],"domain_scores_gemma":[0.9981573,0.00008110474,0.0002392088,0.0006932621,0.0002307503,0.0005984313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005927383,0.0007101602,0.9879581,0.00005328546,0.0002856557,0.009782709,0.0002862729,0.000008103149,0.000008006521,0.0001620644,0.00002735167,0.0001255914],"study_design_scores_gemma":[0.006066602,0.004247196,0.9880208,0.0002814937,0.0002362509,0.0003771254,0.00005660431,0.0000154298,0.00001341221,0.00003820648,0.0003420744,0.0003047912],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948946,0.001113975,0.000002051466,0.000310477,0.0002056626,0.001745621,0.00007354187,0.00003378453,0.001620248],"genre_scores_gemma":[0.997386,0.00055378,0.0001433684,0.0006241898,0.00005482956,0.0005576405,0.0003078774,0.00005363475,0.00031862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02048375,"threshold_uncertainty_score":0.9999715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532012783610585,"score_gpt":0.3245976143428935,"score_spread":0.2992774865067876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}