{"id":"W4293768928","doi":"10.2147/opth.s376199","title":"Early Canadian Real-World Experience with Brolucizumab in Anti-Vascular Endothelial Growth Factor-Experienced Patients with Neovascular Age-Related Macular Degeneration: A Retrospective Chart Review","year":2022,"lang":"en","type":"article","venue":"Clinical ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Dalhousie University; Barrie Urology Group; Centre Intégré de Santé et de Services Sociaux des Laurentides; NOSM University; Sunnybrook Health Science Centre; Centre Hospitalier Universitaire de Sherbrooke","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Macular degeneration; Ophthalmology; Visual acuity; Ranibizumab; Retrospective cohort study; Confidence interval; Branch retinal vein occlusion; Retinal vasculitis; Macular edema; Aflibercept; Retinal; Vasculitis; Surgery; Internal medicine; Bevacizumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001231812,0.00021472,0.0003457897,0.002023744,0.0009678519,0.000990113,0.0006773308,0.0003115703,0.0008839908],"category_scores_gemma":[0.004609924,0.0001987972,0.000326917,0.003816038,0.0005233707,0.0003209625,0.0004244267,0.0002909803,0.0001214022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006813799,"about_ca_system_score_gemma":0.0108744,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5856816,"about_ca_topic_score_gemma":0.6768237,"domain_scores_codex":[0.9982052,0.0001831632,0.0002282442,0.0002076337,0.0009179462,0.0002578207],"domain_scores_gemma":[0.9914888,0.0008667576,0.003663575,0.0002755814,0.00319211,0.0005131573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000974819,0.00002623695,0.9906673,0.0001678139,0.00004273813,0.000775926,0.0005709538,0.00005912058,0.0002126366,0.00004674548,0.0007312765,0.006601803],"study_design_scores_gemma":[0.0000108818,0.00008240446,0.9938626,0.0001018955,0.00004947633,0.001700151,0.0009738269,0.0001541246,0.0002040051,0.000008060521,0.002837189,0.00001543222],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881186,0.00378422,0.0002872997,0.0001730404,0.00001474905,0.0002086352,0.004579454,0.00002046653,0.002813627],"genre_scores_gemma":[0.9952799,0.001560472,0.0003887163,0.0001145423,0.00001373335,0.00004139631,0.002386017,0.000004780788,0.0002103048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4143184,"threshold_uncertainty_score":0.8335168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532012783610585,"score_gpt":0.3245976143428935,"score_spread":0.2992774865067876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}