{"id":"W4293771139","doi":"10.1186/s13195-022-01042-3","title":"Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia","year":2022,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Western University; Montreal Neurological Institute and Hospital; University of Toronto; Occupational Cancer Research Centre; Health Sciences Centre; Sunnybrook Health Science Centre; Université Laval","funders":"NIHR Cambridge Biomedical Research Centre; Sahlgrenska Akademin; Medical Research Council; Olav Thon Stiftelsen; UK Dementia Research Institute; Stichting Dioraphte; Universität Ulm; Universität Duisburg-Essen; Göteborgs Universitet; Deutsches Zentrum für Neurodegenerative Erkrankungen; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Università degli Studi di Milano; EU Joint Programme – Neurodegenerative Disease Research; Università degli Studi di Firenze; Vetenskapsrådet; Cambridge University Hospitals; Stockholms Läns Landsting; KU Leuven; Universidade de Coimbra; Imperial College London; University of Toronto; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Alzheimer Nederland; Eberhard Karls Universität Tübingen; Hjärnfonden; Sahlgrenska Universitetssjukhuset; University of Oxford; ZonMw; University of Cambridge; National Institute for Health and Care Research; Familjen Erling-Perssons Stiftelse; Sunnybrook Research Institute; European Commission; Université de Lille; Weston Brain Institute; Alzheimer's Drug Discovery Foundation; Brain Research UK; Ministero della Salute; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche; Canadian Institutes of Health Research; Alzheimer's Society; Wellcome Trust; Sorbonne Université; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Centre National de la Recherche Scientifique; Wolfson Foundation; McGill University","keywords":"Frontotemporal dementia; Cerebrospinal fluid; Neurology; Dementia; Neuroscience; Medicine; Differential diagnosis; Pathology; Psychiatry; Psychology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087979,0.0006799016,0.0004126508,0.001373487,0.0002889321,0.0005548291,0.0003612273,0.0005402198,0.0008814655],"category_scores_gemma":[0.002887897,0.0001612226,0.0002655972,0.0005233735,0.0004470162,0.0004241335,0.0004584595,0.0003215359,0.0002556099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269547,"about_ca_system_score_gemma":0.0002609392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001837189,"about_ca_topic_score_gemma":0.001576909,"domain_scores_codex":[0.999556,0.00008418372,0.00004501262,0.0001127843,0.0001565656,0.00004535091],"domain_scores_gemma":[0.9991341,0.0002310063,0.000325397,0.00005898467,0.0001494401,0.0001010007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0017595,0.0001983648,0.9455063,0.00006803298,0.0001856736,0.001900685,0.0003440199,0.0004498707,0.03437635,0.00009056651,0.0002488942,0.0148718],"study_design_scores_gemma":[0.00002126993,0.0005145465,0.9862938,0.00002141427,0.00008428328,0.003983944,0.0001785128,0.001512141,0.00688896,0.0002535541,0.0002352262,0.0000123437],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990789,0.0001930649,0.0003444488,0.00001666013,0.000005145061,0.000005792597,0.0001330659,0.00001921067,0.0002037922],"genre_scores_gemma":[0.9992648,0.00005349367,0.0004269121,0.00001386909,0.000004073565,0.000006288831,0.0001659973,0.00000412779,0.00006047001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837189,"threshold_uncertainty_score":0.005753875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0936016053455491,"score_gpt":0.3677850938425485,"score_spread":0.2741834884969994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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