{"id":"W4293773115","doi":"10.1002/jmv.28108","title":"VG161 activates systemic antitumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes","year":2022,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"National Key Research and Development Program of China; China Postdoctoral Science Foundation; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Oncolytic virus; Tumor microenvironment; Pancreatic cancer; Cancer research; Immune system; Immunotherapy; Cancer; Herpes simplex virus; Innate immune system; Biology; Medicine; Immunology; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499307,0.0002890368,0.0002343051,0.0001829073,0.0000693301,0.0003052051,0.0001775906,0.0001842694,0.0005301595],"category_scores_gemma":[0.00005747035,0.00007369745,0.0002115359,0.0001453266,0.0002067619,0.00025445,0.0001617358,0.0005111373,0.0001526101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605889,"about_ca_system_score_gemma":0.0001825721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002334288,"about_ca_topic_score_gemma":0.0002576947,"domain_scores_codex":[0.9998951,0.00001405012,0.000007619588,0.00002897532,0.00002524865,0.00002892725],"domain_scores_gemma":[0.9999641,0.000004007003,0.00001213198,0.000007337129,0.000003447144,0.000008960553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222274,0.0000400348,0.0001637595,0.00002445762,0.000004320279,0.0000226851,0.00001170909,0.0001573101,0.99743,0.000123053,0.00002272316,0.001877731],"study_design_scores_gemma":[0.00001727496,0.0006125943,0.0007584124,0.000004331782,0.00001592459,0.0001358398,0.0000131834,0.0008661148,0.9959889,0.00005803216,0.001527117,0.000002288314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923218,0.001505516,0.004762222,0.00007818143,0.00003161123,0.00004134332,0.0002057129,0.00008090007,0.000972715],"genre_scores_gemma":[0.9941129,0.0008473404,0.003052667,0.00002361664,0.000008584293,0.00003873544,0.0002413943,0.00001651267,0.001658291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005301595,"threshold_uncertainty_score":0.001890719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198263777624166,"score_gpt":0.3277194306165981,"score_spread":0.2957367928403565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}