{"id":"W4293773115","doi":"10.1002/jmv.28108","title":"VG161 activates systemic antitumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes","year":2022,"lang":"en","type":"article","venue":"Journal of Medical Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada)","funders":"National Key Research and Development Program of China; China Postdoctoral Science Foundation; Natural Science Foundation of Zhejiang Province; National Natural Science Foundation of China","keywords":"Oncolytic virus; Tumor microenvironment; Pancreatic cancer; Cancer research; Immune system; Immunotherapy; Cancer; Herpes simplex virus; Innate immune system; Biology; Medicine; Immunology; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002057846,0.0002015278,0.0005199434,0.0002186319,0.0001780399,0.00001669442,0.000854791,0.0002387092,0.0003524961],"category_scores_gemma":[0.0002573679,0.0001817261,0.0001842078,0.0001833643,0.0002123093,0.00001687762,0.0002464229,0.001035812,0.000002082402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897964,"about_ca_system_score_gemma":0.001297241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003701421,"about_ca_topic_score_gemma":0.0001849606,"domain_scores_codex":[0.996907,0.0007908267,0.0007053384,0.0002702402,0.0008788453,0.0004477288],"domain_scores_gemma":[0.9988869,0.0001523804,0.0003279321,0.0003266885,0.00009152129,0.0002146079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005754204,0.0004388962,0.002238135,0.00004442045,0.0002071726,0.0001525735,0.0003304832,0.01457529,0.9720533,0.000007605156,0.000052652,0.004145267],"study_design_scores_gemma":[0.02802448,0.01735154,0.008169699,0.0007217281,0.0002198532,0.006463736,0.003917552,0.03648516,0.8912377,0.0005558588,0.005606928,0.001245785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839293,0.01386025,0.0008970569,0.0007456401,0.0003098578,0.0002076151,0.00001864606,0.000005747817,0.00002589353],"genre_scores_gemma":[0.9967598,0.002114154,0.00007648682,0.0006531716,0.0002408186,0.00007141217,0.000008633835,0.00003869041,0.00003677708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08081563,"threshold_uncertainty_score":0.7410575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198263777624166,"score_gpt":0.3277194306165981,"score_spread":0.2957367928403565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}