{"id":"W4293773667","doi":"10.1101/2022.08.30.505852","title":"β-catenin interacts with the TAZ1 and TAZ2 domains of CBP/p300 to activate gene transcription","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Killam Trusts; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Transactivation; Wnt signaling pathway; Effector; Cell biology; Catenin; Transcription factor; Biology; Regulation of gene expression; Cell fate determination; Gene; Chemistry; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000129225,0.0003439817,0.000162416,0.0001641596,0.0001754593,0.0001959372,0.0003253949,0.0002019399,0.00121456],"category_scores_gemma":[0.0001309235,0.0001552374,0.0003122971,0.0001449689,0.0002294559,0.0001397107,0.000189471,0.0004720006,0.0004549302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004497365,"about_ca_system_score_gemma":0.000164528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132645,"about_ca_topic_score_gemma":0.001274629,"domain_scores_codex":[0.9998828,0.00001352557,0.000005584146,0.0000280288,0.00004591096,0.00002412778],"domain_scores_gemma":[0.9999373,0.00001479503,0.00001495441,0.000007202603,0.000009084733,0.00001680173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000271013,0.000007239315,0.0001164115,0.00001222627,0.000003063471,0.00001509764,0.000004896553,0.00005250988,0.9994025,0.00003851526,0.00001291142,0.000307467],"study_design_scores_gemma":[0.00001197664,0.00005841764,0.003328284,0.00000412946,0.000005835914,0.0001442033,0.0000144879,0.003003394,0.9923729,0.00006045519,0.000990744,0.000005077739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883058,0.001135332,0.009007684,0.00006958268,0.00001815443,0.0000295573,0.0001995256,0.00008160309,0.001152755],"genre_scores_gemma":[0.9954253,0.0002478386,0.00279162,0.00003351798,0.000004238704,0.00002289117,0.0003731652,0.000009849296,0.001091616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121456,"threshold_uncertainty_score":0.004063129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00892900208075375,"score_gpt":0.210041198068591,"score_spread":0.2011121959878372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}