{"id":"W4293776695","doi":"10.3390/cancers14174215","title":"Activation of the Anaphase Promoting Complex Reverses Multiple Drug Resistant Cancer in a Canine Model of Multiple Drug Resistant Lymphoma","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Cancer Society","keywords":"Canine Lymphoma; Cancer research; Drug resistance; Medicine; Lymphoma; Cancer; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002953272,0.0003163521,0.000384835,0.0007351863,0.0002447813,0.0003712205,0.0002308393,0.0003848409,0.001245842],"category_scores_gemma":[0.0002351287,0.0002005547,0.0003073267,0.0002446365,0.0003331069,0.0003108913,0.0001963895,0.0009428095,0.0002388533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005266921,"about_ca_system_score_gemma":0.000254281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009490009,"about_ca_topic_score_gemma":0.002415983,"domain_scores_codex":[0.9997347,0.00004807046,0.00002469328,0.00008006141,0.00005575249,0.0000567651],"domain_scores_gemma":[0.9997323,0.00005116339,0.00009008747,0.00003788748,0.00002486528,0.00006361421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004578504,0.0001654053,0.0004096523,0.00003171405,0.000007448475,0.00006053007,0.00003018699,0.00008154405,0.9973511,0.0001337516,0.0001036483,0.001167249],"study_design_scores_gemma":[0.00009891623,0.003723506,0.007968158,0.00001139763,0.00004419456,0.0006928713,0.00009846954,0.001980282,0.9797217,0.000115514,0.005530545,0.00001460677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99557,0.0008041419,0.0020301,0.0002320772,0.00005030053,0.00007512826,0.0004000314,0.00009919135,0.0007390605],"genre_scores_gemma":[0.9907703,0.0007647697,0.003317074,0.0001332802,0.00002390269,0.0001045546,0.001069881,0.00005591171,0.003760496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001245842,"threshold_uncertainty_score":0.004167795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230439817959662,"score_gpt":0.2655694877198838,"score_spread":0.2425255059239176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}