{"id":"W4293788280","doi":"10.1371/journal.pone.0273825","title":"Functionally impaired isoforms regulate TMPRSS6 proteolytic activity","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"TMPRSS6; Gene isoform; Hepcidin; Biology; Proteases; Alternative splicing; Serine protease; Transmembrane protein; Cell biology; Biochemistry; Protease; Gene; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019597,0.0002948087,0.0002374468,0.0002443357,0.0001680487,0.0003491361,0.0001843188,0.0003545632,0.002615829],"category_scores_gemma":[0.0002177517,0.0001470169,0.0003771182,0.0001312531,0.0002891325,0.0002063365,0.0001766456,0.0005505185,0.000666353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240384,"about_ca_system_score_gemma":0.00015487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005443259,"about_ca_topic_score_gemma":0.0004165572,"domain_scores_codex":[0.9997492,0.00004640946,0.00002194746,0.00004123233,0.00005986433,0.00008132244],"domain_scores_gemma":[0.999828,0.00002953434,0.00006077103,0.000020825,0.00002168565,0.00003919543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002178234,0.00002133128,0.0006467153,0.0000165186,0.000006142236,0.0001070544,0.00001432374,0.0000492023,0.9980305,0.0000777711,0.00006879966,0.0007437485],"study_design_scores_gemma":[0.00003955907,0.0003265594,0.02486429,0.000006572442,0.00003723481,0.001960393,0.0001132598,0.001384196,0.9661682,0.0001606366,0.004927762,0.00001140932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968874,0.0008391863,0.0008363695,0.00008200021,0.00002536199,0.00001206165,0.0003193302,0.00003606928,0.000962269],"genre_scores_gemma":[0.9965265,0.0004127366,0.0006426724,0.00004776026,0.000009229067,0.00001134564,0.0004989246,0.00001866114,0.001832114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002615829,"threshold_uncertainty_score":0.008750856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03554905667408644,"score_gpt":0.2238317365123941,"score_spread":0.1882826798383077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}