{"id":"W4293792854","doi":"10.2174/1574888x17666220831105257","title":"The Molecular and Functional Changes of Neural Stem Cells in Alzheimer’sDisease: Can They be Reinvigorated to Conduct Neurogenesis","year":2022,"lang":"en","type":"review","venue":"Current Stem Cell Research & Therapy","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"","keywords":"Neurogenesis; Neuroscience; Neural stem cell; Hippocampus; Neocortex; Dementia; Tau protein; Psychology; Progenitor cell; Alzheimer's disease; Stem cell; Disease; Biology; Medicine; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003994897,0.000392406,0.0005805948,0.000510524,0.0001768331,0.0008275298,0.0004784083,0.0007497454,0.001366495],"category_scores_gemma":[0.0002974209,0.0001279511,0.0003478029,0.0003836138,0.0003732063,0.001201142,0.0003745279,0.0009218007,0.000854151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003337087,"about_ca_system_score_gemma":0.0004510199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000493454,"about_ca_topic_score_gemma":0.0008460508,"domain_scores_codex":[0.999882,0.00001675321,0.00001936837,0.00002126321,0.00003986582,0.00002082501],"domain_scores_gemma":[0.9999354,0.00001737302,0.000009917879,0.000003905038,0.00002563861,0.000007787885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001984741,0.00009215523,0.0005532489,0.01479445,0.00009059809,0.0006462922,0.0004450617,0.0006028442,0.1008961,0.01392452,0.01973815,0.8480182],"study_design_scores_gemma":[0.00001573256,0.0003464495,0.001603146,0.001091579,0.00009878481,0.001394601,0.000160201,0.0002172308,0.02903163,0.003055708,0.9629562,0.00002865586],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002747162,0.9933965,0.0005989656,0.0004785637,0.0006413478,0.00001273168,0.00003819008,0.00001819879,0.002068248],"genre_scores_gemma":[0.01116699,0.9840996,0.000685754,0.0004998594,0.0003429202,0.00002804921,0.0001034295,0.000007444907,0.003065974],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001366495,"threshold_uncertainty_score":0.004571378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4643633701588344,"score_gpt":0.4189947886440971,"score_spread":0.04536858151473733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}