{"id":"W4293817645","doi":"10.3389/fgene.2022.971298","title":"DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome","year":2022,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Epigenome; DNA methylation; Epigenetics; Disease; Biology; Parkinson's disease; Bioinformatics; Etiology; Genome-wide association study; Epigenomics; Genetics; Computational biology; Medicine; Gene; Single-nucleotide polymorphism; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008218501,0.0003594862,0.0005815166,0.0006788284,0.0002604463,0.0009857523,0.0002646736,0.0005316662,0.001582798],"category_scores_gemma":[0.001447609,0.0001874672,0.0007737129,0.0007482807,0.0004106841,0.0005635848,0.0005502887,0.0006540801,0.0001939687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004396444,"about_ca_system_score_gemma":0.0006965495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002647565,"about_ca_topic_score_gemma":0.003745664,"domain_scores_codex":[0.999586,0.0001492837,0.00003164315,0.0001259429,0.00006932968,0.00003771079],"domain_scores_gemma":[0.9993435,0.0003561038,0.0001519949,0.00002404663,0.00008820679,0.00003622856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001759259,0.0001476911,0.3123305,0.01380812,0.005839989,0.0019264,0.002329864,0.00325268,0.06949633,0.0192815,0.009213648,0.5606141],"study_design_scores_gemma":[0.0000995521,0.001272132,0.7144083,0.004684417,0.006643026,0.005395766,0.001509678,0.004296199,0.02151845,0.03561336,0.2043886,0.0001704801],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2029366,0.7572938,0.0152893,0.01070074,0.0007628042,0.00007511194,0.003018071,0.0001476157,0.009776094],"genre_scores_gemma":[0.6233827,0.3605518,0.008630347,0.002026604,0.0006830632,0.00008973423,0.001325333,0.00003318239,0.003277127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002647565,"threshold_uncertainty_score":0.005294979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02454446464378542,"score_gpt":0.286926807213787,"score_spread":0.2623823425700016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}