{"id":"W4293826739","doi":"10.1128/jvi.00636-22","title":"Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Canada Foundation for Innovation; Canada Research Chairs; Gilead Sciences","keywords":"Gp41; Biology; Glycoprotein; Conformational change; Viral envelope; Virus; Viral entry; Virology; Plasma protein binding; Viral replication; Trimer; Entry inhibitor; Binding site; Molecular biology; Biochemistry; Antibody; Chemistry; Genetics; Epitope","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245682,0.0002042432,0.0001998308,0.0001705454,0.0001339943,0.0002283827,0.0001397811,0.0002150365,0.0009115205],"category_scores_gemma":[0.0002864933,0.0000730749,0.0001709892,0.0001715097,0.00009056589,0.0001033241,0.0000787891,0.0002820647,0.0001867446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338209,"about_ca_system_score_gemma":0.0001017947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007609298,"about_ca_topic_score_gemma":0.0006571158,"domain_scores_codex":[0.9998934,0.00002420836,0.00001138584,0.00001602535,0.00003414675,0.00002080921],"domain_scores_gemma":[0.9999026,0.00003448061,0.00001678747,0.000009086932,0.00001888919,0.00001816534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008859534,0.00006858737,0.000614103,0.000009170081,0.000005530032,0.00006412696,0.0000152032,0.0001532206,0.9975228,0.00004564814,0.00003496354,0.001378071],"study_design_scores_gemma":[0.00004330325,0.002054472,0.01929877,0.000005181526,0.00003923492,0.001215204,0.00007560421,0.002504531,0.9727236,0.00004279336,0.001986558,0.00001085174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985616,0.0001776773,0.0003944091,0.00002890509,0.000006390216,0.00002276763,0.0002753719,0.00001160662,0.0005212699],"genre_scores_gemma":[0.9960325,0.000225544,0.00137149,0.00004796467,0.000006051895,0.00003005929,0.001007307,0.00001680955,0.001262308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009115205,"threshold_uncertainty_score":0.003049374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441573797540366,"score_gpt":0.2667272413258636,"score_spread":0.25231150335046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}