{"id":"W4293870330","doi":"10.31083/j.rcm2308284","title":"The Remaining Conundrum of the Role of the Na+/H+ Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?","year":2022,"lang":"en","type":"review","venue":"Reviews in Cardiovascular Medicine","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; St. Boniface Hospital; University of Manitoba; Western University","funders":"Canadian Institutes of Health Research; University of Wollongong","keywords":"Intracellular pH; Cytosol; Gene isoform; Intracellular; Sodium–hydrogen antiporter; Extracellular; Pharmacology; Cardioprotection; Cell biology; Medicine; Ischemia; Chemistry; Biochemistry; Biology; Internal medicine; Enzyme; Sodium; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006872055,0.0009748478,0.004036526,0.0007339704,0.001298873,0.004064113,0.00305025,0.007031781,0.005688474],"category_scores_gemma":[0.00690951,0.0003931129,0.001290848,0.00105116,0.008584057,0.01495331,0.003070786,0.01315486,0.002771975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001161854,"about_ca_system_score_gemma":0.003927181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396579,"about_ca_topic_score_gemma":0.002049036,"domain_scores_codex":[0.9988404,0.0003258174,0.000151813,0.0002399015,0.0002793638,0.0001627555],"domain_scores_gemma":[0.9938923,0.00318248,0.0004907608,0.0005549102,0.00126351,0.0006160937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002524014,0.0005101826,0.003896933,0.01178767,0.0004742354,0.001586889,0.001468993,0.0009597079,0.02117006,0.06444892,0.1261935,0.7649789],"study_design_scores_gemma":[0.0002594919,0.00196997,0.006141966,0.005842941,0.0005066008,0.00338943,0.005264184,0.001026892,0.004128291,0.2380657,0.7331533,0.0002512112],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004969911,0.717,0.004513438,0.2617069,0.008633898,0.00002309277,0.0001116131,0.00009991098,0.002941314],"genre_scores_gemma":[0.03516009,0.8531156,0.003654007,0.07767857,0.02489604,0.00004812322,0.000212685,0.00006336975,0.005171573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007031781,"threshold_uncertainty_score":0.03634334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03335474843889814,"score_gpt":0.2794071301563091,"score_spread":0.246052381717411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}