{"id":"W4293901999","doi":"10.1161/hypertensionaha.122.19178","title":"Impaired Interleukin-15 Signaling via <i>BMPR2</i> Loss Drives Natural Killer Cell Deficiency and Pulmonary Hypertension","year":2022,"lang":"en","type":"article","venue":"Hypertension","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Queen's University","funders":"Canadian Institutes of Health Research; Lung Health Foundation; Queen's University; British Heart Foundation; Canadian Vascular Network","keywords":"BMPR2; Pulmonary hypertension; Medicine; Immunology; Inflammation; Interleukin; Signal transduction; Endocrinology; Internal medicine; Biology; Cytokine; Cell biology; Bone morphogenetic protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959577,0.0006246979,0.0003803,0.0004719502,0.0001894598,0.0004796437,0.0003762347,0.000526726,0.003775548],"category_scores_gemma":[0.0001202114,0.0003204736,0.000439006,0.0002506581,0.0007020714,0.0002235602,0.0003768268,0.001150612,0.001139311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003192736,"about_ca_system_score_gemma":0.0002019859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004863296,"about_ca_topic_score_gemma":0.0006959866,"domain_scores_codex":[0.9996098,0.00005702251,0.00006626262,0.00008966734,0.0001075505,0.00006971203],"domain_scores_gemma":[0.9996417,0.00003391874,0.0001840943,0.00002587013,0.00001286815,0.0001015473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001430218,0.0000411814,0.0002558372,0.0000347027,0.000009020897,0.0001541123,0.00001441758,0.00006084383,0.9985601,0.0001432636,0.00005917084,0.0005243364],"study_design_scores_gemma":[0.00007320078,0.0003596196,0.005196573,0.00001783423,0.00004665598,0.002028547,0.00007230265,0.001064458,0.9876733,0.00008126291,0.003377874,0.000008347471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888362,0.000903956,0.005367857,0.0002645715,0.00007451921,0.0001028852,0.001735434,0.0002961309,0.002418506],"genre_scores_gemma":[0.9887146,0.000807605,0.003727772,0.0001228966,0.00003080961,0.0001144371,0.001274036,0.0001174293,0.005090422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003775548,"threshold_uncertainty_score":0.0126304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01186759353289602,"score_gpt":0.1935987560631703,"score_spread":0.1817311625302743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}