{"id":"W4293919856","doi":"10.1007/s00018-022-04528-3","title":"Keratin 8 is a scaffolding and regulatory protein of ERAD complexes","year":2022,"lang":"en","type":"article","venue":"Cellular and Molecular Life Sciences","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Chancellerie des Universités de Paris; Agence Nationale de la Recherche; American Breast Cancer Foundation","keywords":"Endoplasmic-reticulum-associated protein degradation; Endoplasmic reticulum; Cell biology; Secretion; Chemistry; Unfolded protein response; Cystic fibrosis transmembrane conductance regulator; Ubiquitin; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002341759,0.00008260932,0.00009793421,0.0000374351,0.0003580153,0.00001782925,0.0001422908,0.00002686523,0.00002457179],"category_scores_gemma":[0.000009348722,0.00007842436,0.00003551671,0.0001055222,0.0002956467,0.000003516576,0.0001306704,0.00004230723,2.411445e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002126549,"about_ca_system_score_gemma":0.00007244695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000164714,"about_ca_topic_score_gemma":0.000002078842,"domain_scores_codex":[0.9992334,0.00004516084,0.0001307629,0.0002966787,0.0001630692,0.0001309628],"domain_scores_gemma":[0.9997176,0.000004308605,0.00005414975,0.0001388866,0.00001510121,0.00006995191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006571348,0.00002053758,0.0003468247,0.00001245081,0.0000118852,0.000001141667,0.00007369568,0.00002584323,0.9962465,0.002529657,0.0002328319,0.0004920696],"study_design_scores_gemma":[0.0002309969,0.000177143,0.0005780378,0.000006626241,0.00001251975,0.00001297819,0.0002829471,0.0002064298,0.9846084,0.0004045671,0.01334542,0.0001339956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927397,0.004664701,0.001642811,0.0003160719,0.00001789048,0.0001767146,0.00004236462,0.000005133445,0.0003946164],"genre_scores_gemma":[0.998403,0.00005992327,0.001043916,0.0003248043,0.00001609188,0.00003213048,0.0000177396,0.000005870794,0.00009650126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01311259,"threshold_uncertainty_score":0.3198053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121379500162811,"score_gpt":0.2320898230534711,"score_spread":0.21995187303719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}