{"id":"W4294069110","doi":"10.1101/2022.08.29.505711","title":"Folate receptor targeted nanoparticles containing niraparib and doxorubicin for treatment of high grade serous ovarian cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Doxorubicin; Ovarian cancer; Folate receptor; Cancer research; Drug delivery; Pharmacology; Chemistry; Targeted drug delivery; Drug; Chemotherapy; Cancer; Cancer cell; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114454,0.0002114523,0.000153129,0.0001786128,0.00006770888,0.0001599467,0.0001177476,0.0002067449,0.002624149],"category_scores_gemma":[0.00007373773,0.00008695501,0.0001388432,0.00008609321,0.00006932356,0.0001553632,0.0001512672,0.0002500253,0.0006232535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036505,"about_ca_system_score_gemma":0.0001104733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002443022,"about_ca_topic_score_gemma":0.000408793,"domain_scores_codex":[0.9999524,0.000007277892,0.000002243463,0.00001081635,0.00001931089,0.000007912608],"domain_scores_gemma":[0.9999858,0.000002937073,0.000004968755,0.000001093698,0.000002557301,0.000002703194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751048,0.00003726031,0.0001493376,0.0001891746,0.00001574721,0.00009359392,0.00001715455,0.001428418,0.9833483,0.000436417,0.001389941,0.01271967],"study_design_scores_gemma":[0.00003368128,0.0002884491,0.0009083766,0.00001518772,0.00002168716,0.0001559203,0.000009844727,0.005587108,0.9824242,0.0001219407,0.01042581,0.000007733253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9377626,0.01119345,0.02976365,0.0009990837,0.0003130932,0.0002125058,0.001401166,0.0006865872,0.01766784],"genre_scores_gemma":[0.9766301,0.0024414,0.01013014,0.000133195,0.00003140092,0.00005505139,0.0005526016,0.00004091829,0.009985151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002624149,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02987567849151285,"score_gpt":0.2784307494570247,"score_spread":0.2485550709655118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}