{"id":"W4294168437","doi":"10.1016/j.biopsych.2022.08.024","title":"Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry","year":2022,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"HEC Montréal; McGill University; Montreal Neurological Institute and Hospital; Institut Universitaire en Santé Mentale de Québec; Université de Montréal; Institut Universitaire de Gériatrie de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Institute of Dental and Craniofacial Research; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Medical Research Council; Fonds de Recherche du Québec - Santé; Fondation Jean-Louis Lévesque; Wellcome Trust; Australian Institute of Sport; Courtois Foundation; Institut de Valorisation des Données; National Institutes of Health; Canada First Research Excellence Fund; National Institute of Biomedical Imaging and Bioengineering; University of California, Los Angeles; Canadian Institutes of Health Research; Simons Foundation; Compute Canada; Innovative Medicines Initiative; National Center for Mental Health; Fondation Brain Canada; MultiCare Institute for Research and Innovation; Simons Foundation Autism Research Initiative; Department of Chemical Engineering and Biotechnology, University of Cambridge; Health and Care Research Wales; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; Takeda Pharmaceutical Company; National Institute for Social Care and Health Research","keywords":"Polygenic risk score; Neuroimaging; Copy-number variation; Psychiatric genetics; Psychiatry; Imaging genetics; Genetic architecture; Medicine; Psychology; Quantitative trait locus; Biology; Schizophrenia (object-oriented programming); Genetics; Gene; Single-nucleotide polymorphism; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007139967,0.0003773554,0.0003152604,0.00115692,0.0005963646,0.0008905106,0.0005013539,0.0007280327,0.005681099],"category_scores_gemma":[0.004860797,0.000296533,0.0004252319,0.001113984,0.0008395475,0.0008312889,0.0005754316,0.0007011577,0.0002324662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584944,"about_ca_system_score_gemma":0.0003499083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007888192,"about_ca_topic_score_gemma":0.01072604,"domain_scores_codex":[0.9993076,0.000256305,0.00003823763,0.0002381902,0.00008451493,0.0000751943],"domain_scores_gemma":[0.9980861,0.0008926535,0.0005530317,0.0002132532,0.0001335653,0.0001213297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001259367,0.000235914,0.9042815,0.0001193783,0.002467501,0.002950416,0.001949383,0.003210862,0.0461677,0.01077301,0.002019777,0.02456517],"study_design_scores_gemma":[0.00002202716,0.00006157506,0.9884193,0.00002783732,0.0002320043,0.001040077,0.0004198434,0.001816483,0.0009440457,0.006407009,0.0005941095,0.00001568852],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959754,0.0003412574,0.001093666,0.0005970121,0.00001880883,0.000005504535,0.0003269579,0.00001502422,0.001626451],"genre_scores_gemma":[0.9989989,0.0001333124,0.0003902099,0.00007117414,0.00001620138,0.000003797567,0.0001089341,0.00001993871,0.0002575524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007888192,"threshold_uncertainty_score":0.01900518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05609652394784507,"score_gpt":0.2898272561848106,"score_spread":0.2337307322369655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}