{"id":"W4294176095","doi":"10.1177/0271678x221122644","title":"The <i>677C &gt; T</i> variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice","year":2022,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute on Aging; Canadian Institutes of Health Research; BrightFocus Foundation","keywords":"Methylenetetrahydrofolate reductase; Internal medicine; Endocrinology; Homocysteine; Medicine; Biology; Chemistry; Allele; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005052537,0.001144544,0.0005682015,0.00105479,0.0005974381,0.0007207707,0.0008342353,0.001792701,0.005297732],"category_scores_gemma":[0.0002862282,0.0007326821,0.001402464,0.0004388723,0.0008958374,0.0003282223,0.000488683,0.002691325,0.001972505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000649126,"about_ca_system_score_gemma":0.0005651084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004135311,"about_ca_topic_score_gemma":0.004386977,"domain_scores_codex":[0.9991785,0.0001279825,0.0001374789,0.000223179,0.0001637374,0.0001691043],"domain_scores_gemma":[0.9991922,0.00009430047,0.000330853,0.0001058558,0.0000491854,0.0002275993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008669012,0.0003477167,0.0004836579,0.00009145906,0.00007763896,0.0005728913,0.00007857617,0.000250972,0.9939386,0.0008406389,0.000610297,0.001840758],"study_design_scores_gemma":[0.0005941337,0.003128407,0.01995111,0.0001934625,0.0004867155,0.003795078,0.0003305752,0.006558539,0.9415233,0.00115988,0.02217996,0.00009884896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679273,0.001219011,0.01205143,0.001681267,0.0005222128,0.0002402985,0.008617622,0.001440727,0.006300125],"genre_scores_gemma":[0.9596606,0.001741741,0.009880689,0.001067494,0.0001456366,0.0004783898,0.005714334,0.0008683372,0.02044283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005297732,"threshold_uncertainty_score":0.01772267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01689152855294546,"score_gpt":0.250481193052473,"score_spread":0.2335896644995275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}