{"id":"W4294193263","doi":"10.1016/j.ijpharm.2022.122141","title":"Intranasal delivery of a synthetic Entamoeba histolytica vaccine containing adjuvant (LecA + GLA-3 M−052 liposomes): In vitro characterization","year":2022,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Adjuvant; Nasal administration; Nasal spray; Medicine; Entamoeba histolytica; Mucous membrane of nose; Immunology; In vitro; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005481021,0.0001369185,0.0003724727,0.0007216944,0.00005056478,0.00001396575,0.000265047,0.00004550929,0.0007852569],"category_scores_gemma":[0.00007568324,0.0001326068,0.000171283,0.0002109999,0.00003917126,0.0001667112,0.00009740499,0.0005535515,0.000004389677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005548282,"about_ca_system_score_gemma":0.0003589826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005710635,"about_ca_topic_score_gemma":0.000001042699,"domain_scores_codex":[0.9977387,0.0001458665,0.0009498243,0.0001324914,0.0008672671,0.0001658185],"domain_scores_gemma":[0.998405,0.0001080501,0.0006715649,0.00009397113,0.000620745,0.0001006675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006439767,0.0006829649,0.006371848,0.00004359044,0.0003342957,0.0008905495,0.001055683,0.0007120518,0.9607261,0.0001018978,0.0000912538,0.02254994],"study_design_scores_gemma":[0.01836156,0.001008636,0.008582585,0.0004210495,0.0005396183,0.003193845,0.001316115,0.03981898,0.8734558,0.00005169123,0.05284881,0.0004013227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941348,0.0004920656,0.0004553255,0.002766941,0.001724706,0.0001732339,0.00005368919,0.00001122653,0.0001880411],"genre_scores_gemma":[0.9970443,0.0003087887,0.0001793933,0.001962159,0.0003297812,0.000004435135,0.00005428476,0.00002246497,0.00009441803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08727037,"threshold_uncertainty_score":0.8598012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024709881258774,"score_gpt":0.3077013661356696,"score_spread":0.2874542673230819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}