{"id":"W4294214970","doi":"10.3389/fonc.2014.00064","title":"Targeting PI3K/Akt/mTOR Signaling in Cancer","year":2014,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1481,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; mTORC2; Signal transduction; Cancer research; RPTOR; Cancer; Phosphatidylinositol; Bench to bedside; mTORC1; Biology; Cell biology; Bioinformatics; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149316,0.0003085163,0.0002721284,0.000602836,0.0002473847,0.0005348771,0.0002258492,0.0003672025,0.0008127994],"category_scores_gemma":[0.00007644214,0.0001206951,0.0001700888,0.0005248539,0.0002916469,0.0004334025,0.0003517936,0.0007271778,0.0004818572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007071886,"about_ca_system_score_gemma":0.0005859958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003664316,"about_ca_topic_score_gemma":0.0009264281,"domain_scores_codex":[0.9999326,0.00001238131,0.000005319367,0.000009285514,0.00002070329,0.00001956823],"domain_scores_gemma":[0.9999793,0.000003113941,0.000004235403,0.000001560786,0.000005207613,0.000006530372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008240052,0.0004565109,0.001026985,0.002467205,0.00005219567,0.0008001123,0.0001652604,0.003010849,0.4051331,0.03494319,0.01738892,0.5337317],"study_design_scores_gemma":[0.0002292421,0.001507461,0.006379339,0.0004446895,0.0001758031,0.004339999,0.0001613233,0.004733472,0.375427,0.02167107,0.5848593,0.0000711797],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1061775,0.8436872,0.01340685,0.008535361,0.001069832,0.00008962015,0.0003073083,0.0004766147,0.02624965],"genre_scores_gemma":[0.3655572,0.6141731,0.009705852,0.001353889,0.0006741882,0.00007037225,0.0002424066,0.00003149863,0.008191469],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008127994,"threshold_uncertainty_score":0.005131066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037513987489954,"score_gpt":0.2896786118852314,"score_spread":0.2793034720103318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}