{"id":"W4294225444","doi":"10.31083/j.fbl2709253","title":"The Role of Epigenetic Regulator SIRT1 in Balancing the Homeostasis and Preventing the Formation of Specific “Soil” of Metabolic Disorders and Related Cancers","year":2022,"lang":"en","type":"review","venue":"Frontiers in Bioscience-Landmark","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Research, Development and Innovation Office; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal; Queen's University; Queen's University Belfast","keywords":"Epigenetics; Regulator; Disease; Inflammation; Calorie restriction; Histone deacetylase; Medicine; Histone; Biology; Obesity; Bioinformatics; Immunology; Cancer research; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460085,0.0003861149,0.0005084171,0.0007415783,0.0002444026,0.0006257494,0.0003951668,0.0005068132,0.00390816],"category_scores_gemma":[0.0003551629,0.0001184249,0.0004314328,0.0005191074,0.0003083113,0.0006589383,0.0004209807,0.0008296722,0.001071154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003229848,"about_ca_system_score_gemma":0.0005086309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005437087,"about_ca_topic_score_gemma":0.001134168,"domain_scores_codex":[0.9998857,0.00002810613,0.00001539678,0.00002395394,0.00003042542,0.00001645456],"domain_scores_gemma":[0.9998997,0.00003233928,0.00001823413,0.000004479234,0.00003451786,0.00001065312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000315963,0.0001138884,0.001317211,0.02564016,0.0003823306,0.001204197,0.0004552094,0.0009101648,0.06000293,0.01708589,0.04922535,0.8433467],"study_design_scores_gemma":[0.00002597918,0.0002263529,0.003464064,0.001129973,0.0002049993,0.001859826,0.0001412723,0.000232243,0.01509167,0.004081906,0.9735048,0.0000369433],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003097048,0.9871668,0.001704811,0.001337586,0.001022541,0.00001545128,0.0001946502,0.00006719153,0.005393927],"genre_scores_gemma":[0.02581803,0.9666241,0.001345467,0.0007646067,0.0006131759,0.00002462235,0.0003352074,0.00001557021,0.004459063],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00390816,"threshold_uncertainty_score":0.0130741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023661266202697,"score_gpt":0.2520012895117185,"score_spread":0.2417646768496916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}