{"id":"W4294243227","doi":"10.1101/2022.09.01.506096","title":"MMD scaffolds ACSL4 and MBOAT7 to promote polyunsaturated phospholipid synthesis and susceptibility to ferroptosis","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Ludwig Center at Harvard; Ludwig Center for Molecular Oncology; Genentech; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Québec Consortium for Drug Discovery; Canadian Cancer Society Research Institute; National Institutes of Health; A Breath of Hope Lung Foundation; Ontario Genomics; Valhalla Foundation; Cancer Research Society; Genome Canada; Advanced Medical Research Foundation; American Society of Clinical Oncology; AstraZeneca; Conquer Cancer Foundation; Fondation Brain Canada; Jane Coffin Childs Memorial Fund for Medical Research; Breast Cancer Research Foundation","keywords":"Arachidonic acid; Cell biology; Polyunsaturated fatty acid; Chemistry; Downregulation and upregulation; Phosphatidylinositol; Lipid raft; Phospholipid; Lipoxygenase; Biochemistry; Cell; Fatty acid; Biology; Enzyme; Signal transduction; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001315093,0.0002951675,0.0002127451,0.0002235097,0.0001371786,0.0002276707,0.000183736,0.0002897053,0.006818599],"category_scores_gemma":[0.0001307511,0.0001013458,0.0001936067,0.000147106,0.0001365656,0.0001979053,0.0002829013,0.0004551465,0.001552851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002957828,"about_ca_system_score_gemma":0.0001945134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004474063,"about_ca_topic_score_gemma":0.0004755779,"domain_scores_codex":[0.999921,0.000008905866,0.000003564571,0.00001389152,0.00003118988,0.00002144563],"domain_scores_gemma":[0.9999604,0.000004771012,0.000009002611,0.000003875056,0.000008395159,0.00001354673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004991734,0.00005169116,0.0004189404,0.0002656726,0.00002634366,0.0001118109,0.0000304931,0.000733489,0.9824895,0.001390104,0.004135095,0.009847693],"study_design_scores_gemma":[0.00005219367,0.0001365037,0.001055029,0.00001608153,0.0000144536,0.00006426497,0.00002600328,0.002278214,0.9762768,0.0002822319,0.01978805,0.00001029477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448525,0.009368122,0.01881363,0.002650528,0.0008569402,0.0001183117,0.005112197,0.001380666,0.01684723],"genre_scores_gemma":[0.9723524,0.002566109,0.006034324,0.0002963993,0.00007272227,0.00006483844,0.002815935,0.00009514978,0.01570218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006818599,"threshold_uncertainty_score":0.02281046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651309039099846,"score_gpt":0.2469647426238959,"score_spread":0.2304516522328974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}