{"id":"W4294251783","doi":"10.1038/s41434-022-00361-2","title":"Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep","year":2022,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Agency of Canada; University of Guelph","funders":"","keywords":"Monoclonal antibody; Biology; Virology; Virus; Antibody; Capsid; Immune system; Immunology; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005576544,0.000217842,0.0004186844,0.0003712265,0.0002354879,0.00002278485,0.0001463231,0.0001300526,0.000370013],"category_scores_gemma":[0.00006856433,0.0001797937,0.000087737,0.0005316362,0.00009124365,0.0001204595,0.0001999703,0.0005053154,0.000004290572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570892,"about_ca_system_score_gemma":0.0001545461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999264,"about_ca_topic_score_gemma":0.00004611638,"domain_scores_codex":[0.9978577,0.0003649782,0.0004080965,0.000405779,0.0005743487,0.0003891296],"domain_scores_gemma":[0.9992271,0.000086157,0.0001771565,0.0002643984,0.0001023146,0.0001428696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001652645,0.0007943049,0.0556515,0.0000497568,0.00004252463,0.0001002468,0.0005175128,0.00005350335,0.9352024,4.547695e-7,0.0001128808,0.005822277],"study_design_scores_gemma":[0.003673567,0.0009663489,0.2179716,0.000157684,0.000007663468,0.00002105136,0.00008020877,0.0004415846,0.7763265,0.00001914141,0.0001711329,0.0001635214],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948158,0.003237103,0.00004456758,0.0001696111,0.00008288143,0.001409446,0.00007684452,0.00006480936,0.00009892132],"genre_scores_gemma":[0.9958226,0.00299648,0.0001369341,0.0001984903,0.00006713204,0.0002838603,0.0002623535,0.0000445995,0.0001875566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1623201,"threshold_uncertainty_score":0.7331773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692614232518118,"score_gpt":0.3192706715774072,"score_spread":0.292344529252226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}