{"id":"W4294275096","doi":"10.1093/humrep/deac188","title":"17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, is an effective spermicide and microbicide against <i>Neisseria gonorrhoeae</i>","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; Ottawa Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Spermicide; Cathelicidin; Sperm; Proteases; In vivo; Biology; Andrology; Sperm motility; Neisseria gonorrhoeae; Antimicrobial peptides; Semen; Antimicrobial; Microbiology; Population; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003403792,0.0001671015,0.000259096,0.00006869667,0.00009403563,0.0002589268,0.0001771235,0.0004562126,0.001021598],"category_scores_gemma":[0.0002840101,0.00007279558,0.0001703098,0.00006468244,0.0001924134,0.000198027,0.0001141995,0.0001959833,0.0001599174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002097531,"about_ca_system_score_gemma":0.0002302396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002941686,"about_ca_topic_score_gemma":0.0003461204,"domain_scores_codex":[0.9998852,0.00003399178,0.00001004328,0.00002023045,0.0000267681,0.0000237081],"domain_scores_gemma":[0.999877,0.0000298615,0.00004713796,0.000006112366,0.00002019449,0.00001976301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007715052,0.00009993517,0.002973234,0.0004385275,0.00002381218,0.0001656253,0.00001916997,0.0001544343,0.9855318,0.0001058679,0.0001684025,0.009547687],"study_design_scores_gemma":[0.0001797896,0.007409619,0.01871429,0.00008499789,0.0001102121,0.002017116,0.0001400594,0.0009305034,0.9627695,0.0001242793,0.007504969,0.00001462977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864239,0.01028013,0.001457996,0.0004462704,0.00003280582,0.00006366074,0.0002258614,0.00001691299,0.001052437],"genre_scores_gemma":[0.9919171,0.004732345,0.001973204,0.0002900461,0.00003578643,0.00004411514,0.0002765942,0.000004746394,0.0007261928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021598,"threshold_uncertainty_score":0.003417552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009308981813299545,"score_gpt":0.2283942679831408,"score_spread":0.2190852861698413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}