{"id":"W4294275096","doi":"10.1093/humrep/deac188","title":"17BIPHE2, an engineered cathelicidin antimicrobial peptide with low susceptibility to proteases, is an effective spermicide and microbicide against <i>Neisseria gonorrhoeae</i>","year":2022,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Ottawa; Ottawa Hospital","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Spermicide; Cathelicidin; Sperm; Proteases; In vivo; Biology; Andrology; Sperm motility; Neisseria gonorrhoeae; Antimicrobial peptides; Semen; Antimicrobial; Microbiology; Population; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0006711396,0.000477538,0.0005329669,0.0002518992,0.001345481,0.00009252989,0.0003040816,0.0001404072,0.0003737682],"category_scores_gemma":[0.00003728769,0.0004739714,0.0001027175,0.0003144536,0.0003227131,0.0004264702,0.0002415378,0.0006226767,0.00005092528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352432,"about_ca_system_score_gemma":0.0000698038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001508318,"about_ca_topic_score_gemma":0.0005425792,"domain_scores_codex":[0.996744,0.0005065998,0.0004260909,0.001661774,0.00004748991,0.0006140389],"domain_scores_gemma":[0.9983943,0.00002657714,0.0002162233,0.001129101,0.0001374306,0.00009638205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009212541,0.0006507221,0.001619364,0.00006940275,0.0001057448,0.000006242025,0.00454509,0.0008618322,0.9847478,0.00004241943,0.002810322,0.003619854],"study_design_scores_gemma":[0.001495846,0.002590813,0.01493518,0.00006896951,0.00009728185,0.0007345655,0.002661093,0.000009245779,0.9678848,0.00004516727,0.008621697,0.0008552918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963441,0.0001903892,0.00007093733,0.0003141368,0.0004411785,0.002056539,0.0002208899,0.0002785833,0.00008326745],"genre_scores_gemma":[0.9961146,0.0000116057,0.0003806292,0.000698203,0.0002793295,0.0002048425,0.000740263,0.00008923779,0.001481317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01686291,"threshold_uncertainty_score":0.9999546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009308981813299545,"score_gpt":0.2283942679831408,"score_spread":0.2190852861698413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}