{"id":"W4294275394","doi":"10.1136/svn-2022-001816","title":"Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850)","year":2022,"lang":"en","type":"article","venue":"Stroke and Vascular Neurology","topic":"Neurological Disorders and Treatments","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Horizon 2020 Framework Programme; British Heart Foundation; Alzheimer’s Society; Fondation Leducq; National Institute for Health and Care Research; Alzheimer's Society","keywords":"Medicine; Lacunar stroke; Tolerability; Cilostazol; Montreal Cognitive Assessment; Internal medicine; Stroke (engine); Modified Rankin Scale; Clinical endpoint; Randomized controlled trial; Dementia; Physical therapy; Adverse effect; Aspirin; Disease; Ischemia; Ischemic stroke","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005437885,0.0001202658,0.0002585695,0.00005419509,0.0002946873,0.00002177065,0.000219036,0.00003148835,0.00002116081],"category_scores_gemma":[0.0003521081,0.0000720739,0.000131258,0.0001190593,0.0001919361,0.00004894735,0.0003079543,0.0001155906,6.802045e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000173066,"about_ca_system_score_gemma":0.00001615775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002126391,"about_ca_topic_score_gemma":0.00002717826,"domain_scores_codex":[0.9984366,0.0005012827,0.0002849875,0.000469125,0.000140414,0.0001676049],"domain_scores_gemma":[0.9979758,0.00141729,0.000183251,0.0003524586,0.00002135191,0.00004988051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.284101,0.01075172,0.2501518,0.001946584,0.006087102,0.0001103678,0.0008394565,0.002351022,0.02527892,0.02418108,0.002023758,0.3921772],"study_design_scores_gemma":[0.08074263,0.03280216,0.27452,0.0000260922,0.01388431,0.00002692246,0.0003448317,0.5612739,0.002477526,0.02007704,0.01320599,0.0006185492],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734933,0.001143202,0.01987258,0.001130954,0.00007681512,0.00175026,0.002520791,0.00000904074,0.000003096682],"genre_scores_gemma":[0.9987784,0.0003822724,0.0001033039,0.0002194736,0.0000166091,0.0002842925,0.0001760545,0.000009665293,0.00002993065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5589229,"threshold_uncertainty_score":0.2939088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0719189831435068,"score_gpt":0.3302961180709414,"score_spread":0.2583771349274346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}