{"id":"W4294281202","doi":"10.1038/s41380-022-01725-1","title":"Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling","year":2022,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Agency for Science, Technology and Research; Hope for Depression Research Foundation","keywords":"Neuroscience; Hippocampal formation; Biology; Chromatin; Nucleus accumbens; Dorsal raphe nucleus; Dentate gyrus; Serotonergic; Genetics; Gene; Dopamine; Receptor; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002628017,0.0002372959,0.000319321,0.000138395,0.0002313128,0.00003895281,0.0003040075,0.00007433865,0.0000174157],"category_scores_gemma":[0.0001574048,0.000242991,0.0001238545,0.0009102907,0.0001444262,0.0001145713,0.0001960043,0.0002858286,0.000001479117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005926687,"about_ca_system_score_gemma":0.00007787866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001713681,"about_ca_topic_score_gemma":0.0001963141,"domain_scores_codex":[0.9977794,0.0005619563,0.0004190393,0.0006102087,0.0002918504,0.0003375683],"domain_scores_gemma":[0.9991378,0.0000901618,0.0002492114,0.0003939146,0.00002888675,0.0001000955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001140718,0.001639851,0.004355063,0.0001353596,0.00005191561,0.0002285776,0.003253393,0.008971751,0.8039523,0.1571683,0.01141116,0.007691592],"study_design_scores_gemma":[0.05110006,0.001858412,0.06114992,0.001042082,0.00018894,0.003468627,0.06023001,0.1451488,0.3452669,0.2429439,0.08062626,0.006975991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684892,0.00298871,0.02484262,0.002388456,0.0005624259,0.0002553776,0.0001013417,0.00006021502,0.0003116072],"genre_scores_gemma":[0.9944306,0.0004265579,0.00319741,0.001697235,0.00004081356,0.00003854905,0.00002432884,0.00003038286,0.0001141261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4586854,"threshold_uncertainty_score":0.9908883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199048997017313,"score_gpt":0.2775460412120113,"score_spread":0.2555555512418382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}