{"id":"W4294281856","doi":"10.1101/2022.09.01.505523","title":"N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Fundação para a Ciência e a Tecnologia; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Hospital for Sick Children; Haukeland Universitetssjukehus; Kreftforeningen; Norges Forskningsråd; Universitetet i Bergen; Vlaamse regering; European Commission; Centre National de la Recherche Scientifique; Universiteit Gent; Fonds Wetenschappelijk Onderzoek","keywords":"Ubiquitin; Ubiquitin ligase; Longevity; Acetylation; Biology; Cell biology; Acetyltransferase; NEDD8; Motility; Drosophila melanogaster; Autophagy; Biochemistry; Genetics; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634457,0.0002606435,0.0002338824,0.0001840027,0.0001580109,0.0002714764,0.0001677066,0.0002696935,0.001556431],"category_scores_gemma":[0.0001187419,0.0001336454,0.0002318875,0.0001002625,0.0001766242,0.0001617681,0.0002421883,0.0005200033,0.0005662477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863363,"about_ca_system_score_gemma":0.0002364354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006168258,"about_ca_topic_score_gemma":0.001156282,"domain_scores_codex":[0.9999001,0.000009946419,0.000008869556,0.00002433901,0.00003384936,0.00002293783],"domain_scores_gemma":[0.9998683,0.000008442322,0.00003696754,0.00001351437,0.0000346332,0.00003816725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002595647,0.00001655984,0.001300773,0.0002205972,0.00002350736,0.0001288364,0.00001345573,0.0001032327,0.9880136,0.0003275924,0.001822835,0.007769302],"study_design_scores_gemma":[0.00004467758,0.0003463923,0.05452917,0.00005502799,0.0001041914,0.001519029,0.00005107023,0.001300777,0.8879982,0.000373954,0.05365228,0.00002528461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9294875,0.04452921,0.009380559,0.002389793,0.0006277269,0.00005833137,0.002942637,0.000733787,0.009850472],"genre_scores_gemma":[0.9753742,0.01118372,0.00155384,0.0004182322,0.0001055866,0.00003117738,0.00146294,0.00005945568,0.009810796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001556431,"threshold_uncertainty_score":0.005206764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982364664458825,"score_gpt":0.2444744994578287,"score_spread":0.2246508528132404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}