{"id":"W4294287452","doi":"10.1021/acs.molpharmaceut.2c00216","title":"Placental Nanoparticle Uptake-On-a-Chip: The Impact of Trophoblast Syncytialization and Shear Stress","year":2022,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Institute of Human Development, Child and Youth Health; Social Sciences and Humanities Research Council of Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"Immunostaining; Placenta; Trophoblast; Cell biology; Forskolin; Chemistry; Confocal microscopy; Flow cytometry; Biophysics; Biology; Fetus; Immunology; Pregnancy; Biochemistry; In vitro; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380764,0.0001177731,0.0001634547,0.00004005381,0.0002091122,0.00000918797,0.0000780907,0.00001965108,0.0001096876],"category_scores_gemma":[0.00002942394,0.00008457345,0.0000909563,0.0001776029,0.00008103633,0.00002261572,0.0001265543,0.0001987752,0.00000212498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006108503,"about_ca_system_score_gemma":0.00004983049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001795972,"about_ca_topic_score_gemma":6.499156e-7,"domain_scores_codex":[0.9991046,0.000129418,0.0001696928,0.0001472386,0.0002718194,0.0001773013],"domain_scores_gemma":[0.999604,0.00004443655,0.00006570411,0.0001916475,0.00002800543,0.0000662103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002356251,0.001214843,0.07075786,0.0002406614,0.001098218,0.0002598204,0.005755589,0.02772084,0.879724,0.001429812,0.001436918,0.008005185],"study_design_scores_gemma":[0.006863891,0.002254206,0.04382237,0.0001583856,0.0005872389,0.0002434185,0.001446238,0.04222774,0.8989921,0.0002553433,0.002799206,0.0003499181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952844,0.002948647,0.0001167145,0.0003690978,0.00008149447,0.0003765268,0.0000745528,0.00002312256,0.0007254362],"genre_scores_gemma":[0.9993154,0.0001725713,0.00004172432,0.0003492702,0.00002088119,0.0000286516,0.00001600393,0.00001768862,0.00003780707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02693549,"threshold_uncertainty_score":0.3448806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0262547646562612,"score_gpt":0.327559578901095,"score_spread":0.3013048142448339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}