{"id":"W4294293131","doi":"10.3390/molecules27175621","title":"Chemical Synthesis and Biological Activities of Amaryllidaceae Alkaloid Norbelladine Derivatives and Precursors","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Butyrylcholinesterase; Alkaloid; Cytotoxic T cell; Cytotoxicity; Stereochemistry; Cell culture; Cholinesterase; Chemistry; Amaryllidaceae; IC50; Biology; Biochemistry; In vitro; Pharmacology; Enzyme; Acetylcholinesterase; Aché","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007926302,0.0001713523,0.0003024563,0.00003115408,0.0001052821,0.00001753947,0.0001462695,0.00007186471,0.0009083961],"category_scores_gemma":[0.0001909412,0.0001490473,0.00006464361,0.0000750041,0.00033221,0.00003394262,0.0003632299,0.0001629073,4.527462e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002580609,"about_ca_system_score_gemma":0.00001102199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001657696,"about_ca_topic_score_gemma":5.690202e-7,"domain_scores_codex":[0.9990916,0.00003589273,0.0001942996,0.0003182289,0.0001600839,0.0001998596],"domain_scores_gemma":[0.9991674,0.000503791,0.00008684225,0.000149306,0.00001115901,0.00008148765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007496525,0.0001019411,0.004236708,0.00008569199,0.00004792206,0.000004711297,0.000199659,0.000001376311,0.9871518,0.000265581,0.00008888382,0.007740748],"study_design_scores_gemma":[0.000162352,0.00002464172,0.000656247,0.0000295122,0.00002157229,0.00002004129,0.0006781262,0.00005180327,0.9959339,0.0003622066,0.001872013,0.0001876212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950354,0.001512506,0.00001020562,0.0002310556,0.00000913754,0.00004052329,0.00009682559,0.00003795839,0.003026387],"genre_scores_gemma":[0.999028,0.0002368079,0.000481637,0.00003790159,0.00002996285,0.00005873921,0.00001209957,0.00001713628,0.00009775386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008782051,"threshold_uncertainty_score":0.99463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109155785131129,"score_gpt":0.2066343695165943,"score_spread":0.195542811665283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}