{"id":"W4294295968","doi":"10.21203/rs.3.rs-1895368/v1","title":"mRNA-LNP expressing PfCSP and Pfs25, two leading vaccine candidates targeting infection and transmission of Plasmodium falciparum","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bloomberg Philanthropies; Johns Hopkins University; George Washington University","keywords":"Virology; Plasmodium falciparum; Transmission (telecommunications); Malaria; Biology; Microbiology; Immunology; Computer science; Telecommunications","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001476,0.0004655138,0.0002059222,0.0001637213,0.0001004693,0.0001453145,0.0001796991,0.0003023942,0.0007167261],"category_scores_gemma":[0.0001458297,0.00009816538,0.0002294104,0.0001136209,0.0001754497,0.0001764644,0.0001284467,0.0004715777,0.0001849367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992044,"about_ca_system_score_gemma":0.0002497549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000724832,"about_ca_topic_score_gemma":0.0006833946,"domain_scores_codex":[0.9998817,0.00001554805,0.000008409457,0.00002572933,0.00003572801,0.00003271241],"domain_scores_gemma":[0.9999455,0.000009227468,0.00001559505,0.000004379614,0.00001087047,0.00001445677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001221529,0.000059525,0.0001476946,0.0000508463,0.000005051124,0.00003205356,0.000007601417,0.0002629882,0.997347,0.00007111475,0.00007502324,0.001819019],"study_design_scores_gemma":[0.00004499619,0.003710652,0.001982492,0.00001067075,0.00004327864,0.0002464961,0.00002443136,0.002356318,0.9883095,0.00004988082,0.003214765,0.000006557832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912372,0.001352559,0.005709359,0.000110862,0.0000982638,0.00008755998,0.0003044804,0.00006871312,0.001030958],"genre_scores_gemma":[0.9916854,0.0007979236,0.004939182,0.00006967722,0.00002442122,0.00007172883,0.0007434348,0.000009896873,0.001658375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000724832,"threshold_uncertainty_score":0.002397656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03904292398604093,"score_gpt":0.3866544816455795,"score_spread":0.3476115576595386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}