{"id":"W4294307609","doi":"10.3390/jpm12091421","title":"Modulator Therapy in Cystic Fibrosis Patients with cis Variants in F508del Complex Allele: A Short-Term Observational Case Series","year":2022,"lang":"en","type":"article","venue":"Journal of Personalized Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cystic fibrosis; Ivacaftor; Medicine; Internal medicine; Observational study; Allele; Compound heterozygosity; Genotype; Sweat test; Body mass index; Gastroenterology; Genetics; Biology; Cystic fibrosis transmembrane conductance regulator; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004679896,0.0003899589,0.0007410863,0.0007248585,0.00106693,0.0007812596,0.0004361531,0.001130167,0.0009252994],"category_scores_gemma":[0.002487162,0.0003220439,0.0009096335,0.0007001104,0.0006217011,0.0005089054,0.000589459,0.0009037512,0.0003054118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000578945,"about_ca_system_score_gemma":0.0006055055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003124813,"about_ca_topic_score_gemma":0.002607784,"domain_scores_codex":[0.9993058,0.0001242942,0.0001316538,0.0001995135,0.0001241599,0.000114571],"domain_scores_gemma":[0.9976351,0.0006226934,0.0008109192,0.0002611966,0.0002063232,0.0004636419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005218518,0.0006866786,0.9595758,0.00006469345,0.0001224311,0.03252543,0.000832543,0.00006448267,0.001216176,0.00004875844,0.000250994,0.004090236],"study_design_scores_gemma":[0.0001596289,0.004140148,0.8281305,0.00006458681,0.0003226967,0.1608372,0.002053493,0.0006479892,0.0009730026,0.0001410127,0.002451594,0.00007810973],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988028,0.0006410658,0.0001477988,0.00004195372,0.000008853015,0.00002440455,0.00007248075,0.000004103339,0.0002566137],"genre_scores_gemma":[0.9990149,0.0003635444,0.0001331882,0.00007661479,0.00004431875,0.00001945265,0.0002177918,0.000003124087,0.0001270551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003124813,"threshold_uncertainty_score":0.006213248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05955668306227999,"score_gpt":0.3359507566275096,"score_spread":0.2763940735652296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}