{"id":"W4294343782","doi":"10.1101/2022.08.31.505752","title":"Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); Canadian Institute for Advanced Research; University of British Columbia","funders":"Canadian Institutes of Health Research; Crohn's and Colitis Canada; University of British Columbia; Killam Trusts; Michael Smith Health Research BC; National Science Foundation","keywords":"Biology; Osmotic shock; Microbiome; In vivo; Relative species abundance; Gut flora; Abundance (ecology); In vitro; Microbial population biology; Osmotic pressure; Bacteria; Ecology; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006151672,0.000372105,0.0005310038,0.000672891,0.0001977318,0.0007243769,0.0002079828,0.0004060376,0.001033985],"category_scores_gemma":[0.001405906,0.0001901829,0.0003396673,0.0005212183,0.0002716217,0.0004045191,0.0004644412,0.0003614898,0.0004113065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001760174,"about_ca_system_score_gemma":0.0001516011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179655,"about_ca_topic_score_gemma":0.00100176,"domain_scores_codex":[0.9996247,0.00007498504,0.00002722421,0.0001287631,0.00009343062,0.00005095013],"domain_scores_gemma":[0.9990696,0.0002266388,0.0003302721,0.00009826184,0.0001577937,0.0001174667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004436636,0.0001357356,0.5960806,0.0001115649,0.0001863534,0.00008114219,0.000114409,0.003591168,0.3867589,0.00007758394,0.0002126745,0.0122062],"study_design_scores_gemma":[0.000006129318,0.000544945,0.9263716,0.0000203771,0.0000608692,0.0003197974,0.0003263816,0.02053723,0.05100362,0.0003626784,0.0004178963,0.0000284913],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961494,0.0002581711,0.002441701,0.00004743503,0.00000902374,0.00001275722,0.0007650137,0.00003000879,0.0002864684],"genre_scores_gemma":[0.9972084,0.0001153363,0.001804658,0.00002788328,0.000006585655,0.00001622072,0.0006483533,0.00001300279,0.0001594932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001179655,"threshold_uncertainty_score":0.003459036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01637620987156351,"score_gpt":0.2389499144666218,"score_spread":0.2225737045950583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}