{"id":"W4294379422","doi":"10.1002/ana.26492","title":"Association of Presynaptic Loss with Alzheimer's Disease and Cognitive Decline","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Canadian Institutes of Health Research; Bristol-Myers Squibb Canada; University of California, San Diego; GE Healthcare; Johnson and Johnson; National Institutes of Health; National Natural Science Foundation of China; Novartis Pharmaceuticals Corporation; Takeda Pharmaceuticals U.S.A.; U.S. Department of Defense; Meso Scale Diagnostics; Roche; University of Southern California; Shenzhen Bay Laboratory; Eli Lilly and Company; Foundation for the National Institutes of Health; Northern California Institute for Research and Education","keywords":"Gap-43 protein; Cerebrospinal fluid; Cognitive decline; Internal medicine; Psychology; Medicine; Pathology; Dementia; Endocrinology; Disease; Immunohistochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005139459,0.000320411,0.0002464689,0.0005691672,0.0003359661,0.0004044624,0.0002403187,0.0004209988,0.001270439],"category_scores_gemma":[0.001948266,0.0001654892,0.0002202615,0.000429747,0.0002264957,0.0003390307,0.0003911237,0.0004256715,0.0001637424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384753,"about_ca_system_score_gemma":0.0001455781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002850175,"about_ca_topic_score_gemma":0.003537644,"domain_scores_codex":[0.9998369,0.00002619632,0.00002286096,0.00005778537,0.00003248131,0.00002363945],"domain_scores_gemma":[0.9986051,0.000300646,0.0006483107,0.0000970147,0.0001652695,0.0001837076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004525342,0.00003860752,0.996208,0.00001279563,0.00005906575,0.0001599253,0.00003558938,0.00004509176,0.001002339,0.00001125725,0.00003294708,0.001941872],"study_design_scores_gemma":[0.000002969709,0.00008613062,0.9991672,0.000002479785,0.00001294475,0.0004513731,0.00002223794,0.0001195332,0.00009627515,0.00001599532,0.00002168218,0.000001206119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992514,0.0003110268,0.00007339368,0.00001759355,0.00000255316,0.000002390274,0.0001056031,0.000004996109,0.0002309196],"genre_scores_gemma":[0.9996297,0.00007702492,0.00008420021,0.000006362973,0.000005364413,0.000002298215,0.00008166935,9.448556e-7,0.000112323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002850175,"threshold_uncertainty_score":0.00566715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04627467219627789,"score_gpt":0.3445419636469834,"score_spread":0.2982672914507055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}