{"id":"W4294495374","doi":"10.1101/2022.08.31.506053","title":"Plasticity in Na <sup>+</sup> /K <sup>+</sup> -ATPase thermal kinetics drives variation in the critical thermal minimum of adult <i>Drosophila melanogaster</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Extracellular; Biophysics; Acclimatization; Ouabain; ATPase; Biology; Drosophila melanogaster; Chemistry; Biochemistry; Sodium; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006881148,0.0002581644,0.000201072,0.0001816234,0.0001411979,0.0003860226,0.0002644861,0.0002631593,0.001657991],"category_scores_gemma":[0.000128568,0.0002211626,0.0002651102,0.00007815357,0.0002400146,0.0002410027,0.0002797241,0.0006659789,0.0005006935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004943113,"about_ca_system_score_gemma":0.0001332547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184192,"about_ca_topic_score_gemma":0.00216004,"domain_scores_codex":[0.9999049,0.000008534235,0.00001403945,0.00003133703,0.00002126684,0.00001996829],"domain_scores_gemma":[0.999793,0.00002050466,0.00007971461,0.00002522208,0.00002881595,0.00005271121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003774326,0.000005946561,0.0003966647,0.00001028275,0.000002438938,0.00001371282,0.000007664938,0.00001815372,0.99919,0.00001812773,0.00002257397,0.0002766677],"study_design_scores_gemma":[0.00001671142,0.000209866,0.1476961,0.00001585076,0.00001775767,0.0001923948,0.0001068518,0.001658263,0.8483689,0.00007633153,0.001622339,0.00001862077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971354,0.0003600978,0.0008713681,0.0000777023,0.00001200138,0.00001182118,0.0005917704,0.00008852438,0.000851316],"genre_scores_gemma":[0.9972512,0.0001457233,0.0005467547,0.00008185369,0.000005554082,0.00002499043,0.0004779985,0.00005629408,0.001409628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001657991,"threshold_uncertainty_score":0.00554651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01245745476574985,"score_gpt":0.2129678688114454,"score_spread":0.2005104140456955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}