{"id":"W4294550968","doi":"10.1016/j.jaip.2022.08.033","title":"Boxed Warnings and Off-Label Use of Allergy Medications: Risks, Benefits, and Shared Decision Making","year":2022,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"American Academy of Allergy, Asthma and Immunology Foundation","keywords":"Medicine; Harm; Package insert; Food and drug administration; Off-label use; Drug; Obligation; Medical emergency; Clinical trial; Drug labeling; MEDLINE; Family medicine; Intensive care medicine; Psychiatry; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004044146,0.0001190712,0.0004553899,0.00008994398,0.0002973285,0.00001851512,0.0001591943,0.0001172152,0.0001438913],"category_scores_gemma":[0.009962903,0.00008113292,0.00004794574,0.0001672657,0.0004391134,0.0004618769,0.0004902179,0.001560118,7.758798e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002415477,"about_ca_system_score_gemma":0.0000791018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062073,"about_ca_topic_score_gemma":0.00004412848,"domain_scores_codex":[0.9972277,0.001081464,0.001069905,0.0001604979,0.0002838699,0.000176588],"domain_scores_gemma":[0.98028,0.0179632,0.001288932,0.0001734696,0.0002081981,0.00008613052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.06285337,0.003097692,0.02279671,0.00002772361,0.02090276,0.0003214345,0.005267036,0.0001113575,0.0006828612,0.001980457,0.002437622,0.879521],"study_design_scores_gemma":[0.01083175,0.005437433,0.441892,0.0004389385,0.002883326,0.005238092,0.008562854,0.002608192,0.00001402636,0.001019881,0.5208346,0.0002389432],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8483693,0.1271805,0.00003532326,0.02393976,0.0002415051,0.0001192477,0.00000438196,0.00000463646,0.0001053772],"genre_scores_gemma":[0.4329897,0.5621038,0.002183053,0.002627426,0.00005501828,0.000003420711,0.000001344334,0.000009545979,0.00002669494],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8792821,"threshold_uncertainty_score":0.9983766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.159101113386095,"score_gpt":0.4589371140878487,"score_spread":0.2998360007017536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}