{"id":"W4294577824","doi":"10.1358/dot.2022.58.9.3422313","title":"Efficacy of vosoritide in the treatment of achondroplasia","year":2022,"lang":"en","type":"article","venue":"Drugs of today","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Achondroplasia; Medicine; Endocrinology; Natriuretic peptide; Internal medicine; Dwarfism; Mutation; NPR2; Fibroblast growth factor receptor 3; Guanosine; Mutant; Receptor; Genetics; Fibroblast growth factor; Gene; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002087576,0.0002219973,0.0004249401,0.0003245946,0.0001302632,0.0001938988,0.0002428903,0.0004157749,0.001466141],"category_scores_gemma":[0.0003228065,0.00005583826,0.0003808574,0.0001608823,0.0001210679,0.0001648272,0.0001268969,0.0006011302,0.0002507226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000173993,"about_ca_system_score_gemma":0.0002044437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008450042,"about_ca_topic_score_gemma":0.001171546,"domain_scores_codex":[0.9998935,0.0000312695,0.000009623288,0.00001450192,0.00002933167,0.00002168577],"domain_scores_gemma":[0.9998788,0.00003272043,0.00001894206,0.000006242825,0.00001791569,0.0000454321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.05363142,0.008687007,0.006177542,0.002617585,0.0009221969,0.001717525,0.0001872422,0.001237604,0.2565854,0.0009970475,0.002764418,0.664475],"study_design_scores_gemma":[0.03955803,0.2770472,0.2240251,0.001588944,0.002409081,0.01138828,0.0006234829,0.005459172,0.288619,0.001231916,0.1479216,0.0001281437],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9083071,0.07710364,0.0009731677,0.0007290413,0.0003193092,0.0001975271,0.0003562177,0.0002064109,0.01180761],"genre_scores_gemma":[0.9828728,0.01246977,0.0007649902,0.0002422632,0.00009296106,0.00004772592,0.0002798945,0.00001426555,0.003215353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001466141,"threshold_uncertainty_score":0.004904807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305993269531803,"score_gpt":0.2960372429706298,"score_spread":0.2829773102753118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}