{"id":"W4294577824","doi":"10.1358/dot.2022.58.9.3422313","title":"Efficacy of vosoritide in the treatment of achondroplasia","year":2022,"lang":"en","type":"article","venue":"Drugs of today","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Achondroplasia; Medicine; Endocrinology; Natriuretic peptide; Internal medicine; Dwarfism; Mutation; NPR2; Fibroblast growth factor receptor 3; Guanosine; Mutant; Receptor; Genetics; Fibroblast growth factor; Gene; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001583913,0.00005703366,0.0001231862,0.00005024132,0.00002215714,0.000001163679,0.0002151997,0.0000211184,0.00007339927],"category_scores_gemma":[0.00005636307,0.00004553573,0.00008030463,0.0001266507,0.00006386908,8.194031e-7,0.00006295352,0.00003891765,6.323788e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001446003,"about_ca_system_score_gemma":0.0000464149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164715,"about_ca_topic_score_gemma":0.00004469107,"domain_scores_codex":[0.9993219,0.0001334502,0.0001498099,0.000124416,0.0001699175,0.0001005349],"domain_scores_gemma":[0.9995555,0.0000653832,0.00005896041,0.000272247,0.00003623706,0.00001167595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007980052,0.00290092,0.03814626,0.00005536017,0.0001368887,0.000007413325,0.006308454,0.0004678903,0.9152518,0.0004895922,0.001098862,0.03433858],"study_design_scores_gemma":[0.003645932,0.003423094,0.06376454,0.00001002193,0.00002242753,0.000005565353,0.005150767,0.00003200244,0.8636045,0.0001586226,0.06004732,0.0001352444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963133,0.001336833,0.000005318585,0.0002084111,0.00002459245,0.0002256394,0.00003959667,8.757415e-7,0.00184545],"genre_scores_gemma":[0.9994286,0.0001363031,0.0000294089,0.00001061747,0.0000125118,0.0000402309,0.00004193751,0.000006191211,0.0002941787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05894845,"threshold_uncertainty_score":0.1856893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305993269531803,"score_gpt":0.2960372429706298,"score_spread":0.2829773102753118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}