{"id":"W4294579442","doi":"10.1177/10738584221120182","title":"Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD","year":2022,"lang":"en","type":"article","venue":"The Neuroscientist","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Snow Foundation; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Macquarie University; Motor Neurone Disease Australia; FightMND","keywords":"Amyotrophic lateral sclerosis; Frontotemporal dementia; Neurodegeneration; Ubiquitin ligase; Neuroscience; Biology; Motor neuron; C9orf72; Ubiquitin; Dementia; Disease; Genetics; Gene; Spinal cord; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881602,0.0004780867,0.0007131881,0.001607741,0.0002736969,0.0009236333,0.000354715,0.0009481134,0.001479282],"category_scores_gemma":[0.0003200748,0.0001574339,0.0002090415,0.001177723,0.0003870898,0.0009864513,0.0004027725,0.0009228719,0.0005496984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007145593,"about_ca_system_score_gemma":0.0004959449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001532025,"about_ca_topic_score_gemma":0.003020642,"domain_scores_codex":[0.9998931,0.00001478639,0.00001986704,0.00001967926,0.00003756155,0.0000149639],"domain_scores_gemma":[0.9998972,0.00003740913,0.00002264409,0.000002033669,0.00002605081,0.00001454735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000340397,0.000088698,0.002287953,0.01324651,0.0001834461,0.003412976,0.0005507576,0.0005567098,0.01298584,0.009200933,0.0604177,0.8967281],"study_design_scores_gemma":[0.00002464622,0.0001545134,0.00420148,0.002003144,0.0001291553,0.007422145,0.0002757254,0.0000982784,0.001356704,0.004104752,0.9801971,0.00003225184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004381172,0.9985948,0.00004535477,0.0002170886,0.0001584393,0.000001147927,0.000009877379,0.00000348249,0.0005316579],"genre_scores_gemma":[0.002820157,0.9956897,0.0001010057,0.0001951338,0.000521699,0.000003334797,0.00003175169,0.000001255945,0.0006359818],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001607741,"threshold_uncertainty_score":0.005184472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01798679381572783,"score_gpt":0.2596042557538186,"score_spread":0.2416174619380907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}