{"id":"W4294605794","doi":"10.1002/mds.29216","title":"No Association Between Rare <scp><i>TWNK</i></scp> Variants and Parkinson's Disease in European Cohorts","year":2022,"lang":"en","type":"letter","venue":"Movement Disorders","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Parkinson Canada; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Association (psychology); Disease; Medicine; Neuroscience; Genetics; Psychology; Biology; Internal medicine; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002901061,0.0003167723,0.0002476765,0.0001125054,0.0001208761,0.0000778129,0.0002212296,0.0002233509,0.0001358193],"category_scores_gemma":[0.0002372304,0.0003593237,0.0001319196,0.0001043404,0.00003461692,0.000008052206,0.0002635314,0.0003662437,0.00002017135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065526,"about_ca_system_score_gemma":0.00008323374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006092787,"about_ca_topic_score_gemma":0.00002881398,"domain_scores_codex":[0.9978175,0.0003703075,0.0003142072,0.0006644345,0.0004272477,0.0004063635],"domain_scores_gemma":[0.9991208,0.00004445475,0.0002554802,0.000391745,0.00003807958,0.0001494834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001116893,0.00004349009,0.4016407,0.00005479914,0.00008525873,0.00003703593,0.0000177386,0.00003482537,0.00007161531,0.000002109561,0.5976856,0.0003156625],"study_design_scores_gemma":[0.0006393642,0.00005407075,0.3159339,0.00001367049,0.0000625528,2.59071e-8,0.00001923989,0.00001825481,0.000006594226,0.0002539111,0.6828598,0.0001385673],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.7048345,0.004787216,0.000242675,0.2300206,0.001707111,0.003442003,0.00350915,0.0001624196,0.05129438],"genre_scores_gemma":[0.1880741,0.001760547,0.00004742464,0.7418801,0.002214114,0.0002599936,0.02196694,0.0002188509,0.04357796],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5167603,"threshold_uncertainty_score":0.9998859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005573936995009763,"score_gpt":0.2041543589664282,"score_spread":0.1985804219714185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}