{"id":"W4294605794","doi":"10.1002/mds.29216","title":"No Association Between Rare <scp><i>TWNK</i></scp> Variants and Parkinson's Disease in European Cohorts","year":2022,"lang":"en","type":"letter","venue":"Movement Disorders","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Parkinson Canada; Canada First Research Excellence Fund; Consortium canadien en neurodégénérescence associée au vieillissement; Medical Research Council; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkinson's disease; Association (psychology); Disease; Medicine; Neuroscience; Genetics; Psychology; Biology; Internal medicine; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001683701,0.0004868548,0.0009105023,0.0004565729,0.001606483,0.001224668,0.0009347684,0.0144495,0.004015283],"category_scores_gemma":[0.01075605,0.0004063569,0.0005648179,0.0005566486,0.001427554,0.000783169,0.0004954578,0.006028855,0.002343318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009875585,"about_ca_system_score_gemma":0.0009383878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006016694,"about_ca_topic_score_gemma":0.008700294,"domain_scores_codex":[0.9988954,0.000302861,0.000141088,0.0002637907,0.0002192467,0.0001775737],"domain_scores_gemma":[0.9917614,0.005602561,0.0005250311,0.0003648696,0.000799334,0.0009467831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.002684643,0.000140436,0.06860149,0.0002625055,0.0004424333,0.05479996,0.0007625085,0.0004716532,0.003508774,0.004994431,0.8198624,0.04346879],"study_design_scores_gemma":[0.003433368,0.001268052,0.1784785,0.001180659,0.001522043,0.09498169,0.002623264,0.0058636,0.004631858,0.05735636,0.6481492,0.0005115498],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04254683,0.004584702,0.0007314925,0.9056284,0.03037763,0.00003176236,0.001257991,0.0001266436,0.01471457],"genre_scores_gemma":[0.2998013,0.003209362,0.000707971,0.5987524,0.0811443,0.00009146423,0.0004760213,0.0001216532,0.01569554],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0144495,"threshold_uncertainty_score":0.0134325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005573936995009763,"score_gpt":0.2041543589664282,"score_spread":0.1985804219714185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}