{"id":"W4294636674","doi":"10.1038/s41589-022-01119-y","title":"A genetic platform to investigate the functions of bacterial drug efflux pumps","year":2022,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Efflux; Escherichia coli; Biology; Strain (injury); Drug discovery; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636933,0.0001804053,0.0002121661,0.00005829816,0.000134362,0.000008600721,0.0006295482,0.0005063774,0.0002007057],"category_scores_gemma":[0.0001664768,0.000134264,0.0001156346,0.0002435527,0.000276306,0.000001077278,0.0008947091,0.0005694018,0.000009496108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002347253,"about_ca_system_score_gemma":0.00009156527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001914091,"about_ca_topic_score_gemma":0.00001630987,"domain_scores_codex":[0.9987962,0.00007214855,0.0002786693,0.0004378471,0.00009405105,0.0003210992],"domain_scores_gemma":[0.9992153,0.00003046023,0.0001050252,0.0004912007,0.00006642629,0.00009160201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001783316,0.00004568627,0.0004067604,0.000005089982,0.00004843134,5.961729e-7,0.00002552435,0.00001177899,0.990275,0.0002664418,0.006809503,0.001926805],"study_design_scores_gemma":[0.0002973732,0.0003004188,0.0004576177,0.000001416453,0.00001731117,0.00003219572,0.00003319703,0.000004407405,0.6734601,0.0003771304,0.3248821,0.0001366867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956638,0.0005301408,0.00002930869,0.002034674,0.00100037,0.0002687895,0.0002449444,0.00001822897,0.0002097541],"genre_scores_gemma":[0.9965919,0.00003444945,0.0006225175,0.001467892,0.000552898,0.00009566339,0.0004289377,0.00001974167,0.0001860282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3180726,"threshold_uncertainty_score":0.5475129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005534699971036432,"score_gpt":0.2187999218555206,"score_spread":0.2132652218844842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}