{"id":"W4294647389","doi":"10.1186/s13063-022-06589-y","title":"Efficacy and safety of guselkumab in biologic-naïve patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"Janssen Scientific Affairs","keywords":"Medicine; BASDAI; Psoriatic arthritis; Placebo; Internal medicine; Clinical endpoint; Secukinumab; Ankylosing spondylitis; BASFI; Randomized controlled trial; Arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01417171,0.005185709,0.007381415,0.001142867,0.00223749,0.002400384,0.003137559,0.005418457,0.02852971],"category_scores_gemma":[0.01211002,0.002407055,0.003642041,0.001391934,0.002816908,0.002797297,0.001214323,0.005807893,0.007041159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002418427,"about_ca_system_score_gemma":0.01023234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001107671,"about_ca_topic_score_gemma":0.00321731,"domain_scores_codex":[0.9921159,0.004574521,0.0007676525,0.0009252144,0.0007906326,0.0008259731],"domain_scores_gemma":[0.9956307,0.0006978714,0.001105854,0.0005278435,0.000839984,0.001197759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9632549,0.008383293,0.000658574,0.004894471,0.0009378769,0.000108918,0.0001276232,0.0006307143,0.002420004,0.0007761779,0.006139645,0.01166781],"study_design_scores_gemma":[0.9735861,0.01697596,0.00108819,0.0003822496,0.0003962535,0.00004043524,0.00002808611,0.0005011183,0.0003063131,0.0004584827,0.006201262,0.00003557521],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02984913,0.001953318,0.003337777,0.0007968996,0.0007156515,0.9556305,0.004404849,0.0003095832,0.003002255],"genre_scores_gemma":[0.03067272,0.001009501,0.005406761,0.00108444,0.0002527755,0.9581813,0.001619801,0.00002766022,0.001745051],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02852971,"threshold_uncertainty_score":0.09544134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07977662624239434,"score_gpt":0.4026906844077134,"score_spread":0.322914058165319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}