{"id":"W4294647459","doi":"10.1186/s13287-022-03144-z","title":"Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; ReumaNederland; Dutch Arthritis Society","keywords":"CD90; Mesenchymal stem cell; Synovial membrane; Progenitor cell; CD34; Chondrogenesis; CD44; Osteoarthritis; Population; Synovitis; Medicine; Pathology; Stem cell; Cartilage; Synovial fluid; Inflammation; Arthritis; Immunology; Cell; Chemistry; Biology; Cell biology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001122456,0.0005109546,0.000893361,0.0006158444,0.0005968863,0.0001463966,0.0004254078,0.0001901358,0.003078442],"category_scores_gemma":[0.00001471896,0.0004921159,0.0002414253,0.0008676685,0.0002370492,0.0002213851,0.0004497367,0.001085424,0.0002700772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004998024,"about_ca_system_score_gemma":0.0005072658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007229995,"about_ca_topic_score_gemma":0.000535838,"domain_scores_codex":[0.9937554,0.001076482,0.0006801058,0.001141775,0.001894556,0.001451702],"domain_scores_gemma":[0.997619,0.0003618326,0.0001076217,0.0008272001,0.0002677515,0.0008166317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005167615,0.001069442,0.001804803,0.0000670691,0.00009767112,0.001013268,0.002605832,0.000005176567,0.9782479,0.0000170099,0.0002482563,0.009655964],"study_design_scores_gemma":[0.02181604,0.008619176,0.002410593,0.0001645203,0.00004872723,0.00009906798,0.001886192,0.00002160001,0.9573376,0.0001103727,0.006883945,0.0006021655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900457,0.002552317,0.000001149734,0.0005265158,0.001057993,0.004176202,0.0003176621,0.0001016183,0.00122086],"genre_scores_gemma":[0.9946205,0.0002741616,0.0003945259,0.0003099673,0.0002918704,0.0009516348,0.0001161302,0.0001249493,0.002916271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02091029,"threshold_uncertainty_score":0.9997531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0566542227214502,"score_gpt":0.3014412564992066,"score_spread":0.2447870337777563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}