{"id":"W4294647459","doi":"10.1186/s13287-022-03144-z","title":"Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stichting voor de Technische Wetenschappen; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Arthritis Society; ReumaNederland; Dutch Arthritis Society","keywords":"CD90; Mesenchymal stem cell; Synovial membrane; Progenitor cell; CD34; Chondrogenesis; CD44; Osteoarthritis; Population; Synovitis; Medicine; Pathology; Stem cell; Cartilage; Synovial fluid; Inflammation; Arthritis; Immunology; Cell; Chemistry; Biology; Cell biology; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003339635,0.0002595455,0.0003297108,0.0009423147,0.0002485105,0.0004859551,0.000173183,0.0003044089,0.002041876],"category_scores_gemma":[0.0003123102,0.0002124753,0.0002983715,0.0003591384,0.0003587054,0.0002979593,0.0003471666,0.0004763419,0.0006032777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730898,"about_ca_system_score_gemma":0.0003115869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008232053,"about_ca_topic_score_gemma":0.001265033,"domain_scores_codex":[0.9996402,0.00002846345,0.00005339437,0.00006856078,0.0001474094,0.00006191428],"domain_scores_gemma":[0.999684,0.00004078861,0.0001224801,0.00002714121,0.00005592742,0.00006967971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005749452,0.00009601093,0.0141061,0.0002219051,0.00002202596,0.0004765702,0.0002115209,0.0001117487,0.9788929,0.0001373305,0.00009565487,0.005053299],"study_design_scores_gemma":[0.00009174332,0.005067986,0.2454461,0.00009535912,0.0002179345,0.0118121,0.001863193,0.002223481,0.720018,0.0002560834,0.01286894,0.00003908827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968021,0.0009458939,0.001324236,0.00002858785,0.00001213033,0.00003403066,0.0002692073,0.00002131368,0.0005623958],"genre_scores_gemma":[0.9955642,0.0004702274,0.001763836,0.00003208629,0.00001284204,0.0000432722,0.0009690509,0.000009668142,0.00113479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041876,"threshold_uncertainty_score":0.006830752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0566542227214502,"score_gpt":0.3014412564992066,"score_spread":0.2447870337777563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}