{"id":"W4294647492","doi":"10.1186/s12974-022-02573-0","title":"Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study","year":2022,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Hospital; Occupational Cancer Research Centre; Université Laval; Western University","funders":"Institute on the Environment, University of Minnesota; Medical Research Council; Demensfonden; UK Dementia Research Institute; Stichting Dioraphte; Università degli Studi di Brescia; Universidade de Lisboa; Deutsches Zentrum für Neurodegenerative Erkrankungen; Università degli Studi di Firenze; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Horizon 2020 Framework Programme; Stockholms Läns Landsting; KU Leuven; University Health Network; Hjärnfonden; Universidade de Coimbra; University of Toronto; Universität Ulm; Toronto Rehabilitation Institute; Erasmus Medisch Centrum; University of Oxford; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Eberhard Karls Universität Tübingen; King's College London; Ludwig-Maximilians-Universität München; National Institute for Health and Care Research; McGill University; Deutsche Forschungsgemeinschaft; Brain Research UK; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer Nederland; Sunnybrook Research Institute; Robarts Research Institute; Alzheimer's Society; Wellcome Trust; Gun och Bertil Stohnes Stiftelse; London School of Hygiene and Tropical Medicine; Università degli Studi di Milano; Karolinska Institutet; ZonMw; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association","keywords":"Frontotemporal dementia; C9orf72; Frontotemporal lobar degeneration; Dementia; Complement system; Pathology; Grey matter; Medicine; Immunology; Psychology; Disease; White matter; Antibody; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008817051,0.0001773773,0.0002243666,0.000215088,0.000456924,0.0001585316,0.0003876691,0.00002085097,0.0001079478],"category_scores_gemma":[0.000561699,0.0001446717,0.00005905575,0.0003531042,0.00003117748,0.0003433538,0.0001988332,0.0004724142,0.000006795155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006269386,"about_ca_system_score_gemma":0.0000838098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003584665,"about_ca_topic_score_gemma":0.0001299959,"domain_scores_codex":[0.99573,0.001484518,0.001269617,0.0003528839,0.0009599191,0.0002030875],"domain_scores_gemma":[0.9981583,0.0003644702,0.001031476,0.0002934023,0.00007508002,0.00007722266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005586007,0.0002419781,0.002180007,0.000003336335,0.00001170136,0.0003305032,0.001885369,0.009057667,0.9837013,0.000226314,0.0003871842,0.001416003],"study_design_scores_gemma":[0.01824294,0.004272649,0.3026049,0.00003435621,0.0001470932,0.0007161801,0.002173327,0.0927721,0.5690848,0.001833538,0.007505897,0.0006121764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995276,0.00001785644,0.0002215819,0.002752053,0.0004742632,0.001133006,0.00004209656,0.00002618064,0.00005693655],"genre_scores_gemma":[0.9991142,0.00002771674,0.0003474632,0.0002675606,0.0001387872,0.00003471551,0.000006647195,0.00002208337,0.00004079524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4146165,"threshold_uncertainty_score":0.5899541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634916014458195,"score_gpt":0.2612127635326956,"score_spread":0.2148636033881136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}