{"id":"W4294647492","doi":"10.1186/s12974-022-02573-0","title":"Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study","year":2022,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; University of Toronto; Sunnybrook Hospital; Occupational Cancer Research Centre; Université Laval; Western University","funders":"Institute on the Environment, University of Minnesota; Medical Research Council; Demensfonden; UK Dementia Research Institute; Stichting Dioraphte; Università degli Studi di Brescia; Universidade de Lisboa; Deutsches Zentrum für Neurodegenerative Erkrankungen; Università degli Studi di Firenze; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Horizon 2020 Framework Programme; Stockholms Läns Landsting; KU Leuven; University Health Network; Hjärnfonden; Universidade de Coimbra; University of Toronto; Universität Ulm; Toronto Rehabilitation Institute; Erasmus Medisch Centrum; University of Oxford; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Eberhard Karls Universität Tübingen; King's College London; Ludwig-Maximilians-Universität München; National Institute for Health and Care Research; McGill University; Deutsche Forschungsgemeinschaft; Brain Research UK; EU Joint Programme – Neurodegenerative Disease Research; Alzheimer Nederland; Sunnybrook Research Institute; Robarts Research Institute; Alzheimer's Society; Wellcome Trust; Gun och Bertil Stohnes Stiftelse; London School of Hygiene and Tropical Medicine; Università degli Studi di Milano; Karolinska Institutet; ZonMw; Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta; Stiftelsen för Gamla Tjänarinnor; Alzheimer's Association","keywords":"Frontotemporal dementia; C9orf72; Frontotemporal lobar degeneration; Dementia; Complement system; Pathology; Grey matter; Medicine; Immunology; Psychology; Disease; White matter; Antibody; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001225657,0.0008010799,0.0004755519,0.0007839791,0.0005575106,0.0007585605,0.0005572647,0.0007508536,0.0008992745],"category_scores_gemma":[0.002003384,0.0002729633,0.0006199955,0.0007926486,0.0003744508,0.0002813286,0.0006445204,0.0005182985,0.0002495835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006307593,"about_ca_system_score_gemma":0.0003359586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01349732,"about_ca_topic_score_gemma":0.01514651,"domain_scores_codex":[0.9995646,0.00009262718,0.00003542839,0.0001609278,0.00008252767,0.00006389438],"domain_scores_gemma":[0.9990257,0.0001535335,0.0003217635,0.0001283559,0.0001489859,0.0002216397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006675279,0.00004741282,0.9965836,0.00001651209,0.0001923113,0.000364153,0.0002435106,0.00003021832,0.0004499445,0.00001395697,0.0001812919,0.001209497],"study_design_scores_gemma":[0.0000218733,0.00007411324,0.9992117,0.00000559613,0.00008328939,0.0003067073,0.00008199708,0.00003255469,0.00004723678,0.00001215585,0.0001196778,0.000003123467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990699,0.0002041247,0.00002411586,0.00002224019,0.00000392636,0.000007406397,0.0004770192,0.000002023935,0.0001892205],"genre_scores_gemma":[0.9987722,0.0000849159,0.00007467349,0.00003298095,0.00000849229,0.0000122386,0.0008850706,0.000001899181,0.0001275535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01349732,"threshold_uncertainty_score":0.02683753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04634916014458195,"score_gpt":0.2612127635326956,"score_spread":0.2148636033881136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}