{"id":"W4294659898","doi":"10.1093/brain/awac315","title":"Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Institut Universitaire de Gériatrie de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. National Library of Medicine; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Canada First Research Excellence Fund; National Institute of Dental and Craniofacial Research; Centre Hospitalier Universitaire Vaudois; Simons Foundation; Health and Care Research Wales; Courtois Foundation; Wellcome Trust; National Institute on Drug Abuse; Institut de Valorisation des Données; Fondation Brain Canada; Canadian Institutes of Health Research; Compute Canada","keywords":"Functional connectivity; Pleiotropy; Neuroscience; Psychology; Psychiatry; Genetics; Biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003116851,0.0001158804,0.0001088228,0.0001809075,0.0002329374,0.0000159248,0.0001562505,0.00006304825,0.001068014],"category_scores_gemma":[0.0002342129,0.0001382583,0.00009757138,0.000406888,0.00006620603,0.000003212479,0.0002459144,0.0002400867,0.00004835696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006349343,"about_ca_system_score_gemma":0.0002190187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001250997,"about_ca_topic_score_gemma":0.0007969221,"domain_scores_codex":[0.9985356,0.0003373435,0.0001669942,0.0003920886,0.0002532272,0.000314782],"domain_scores_gemma":[0.999447,0.0001129307,0.00003184017,0.0002873399,0.00003350331,0.00008734385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003840343,0.0005905217,0.08832387,0.00003314564,0.00008126999,0.0000703875,0.00008390202,0.001070823,0.7468337,0.000761189,0.1575263,0.004240822],"study_design_scores_gemma":[0.002185314,0.0009255964,0.7780204,0.000002836581,0.00000933682,0.0002171009,0.0001621286,0.0006907641,0.003208598,0.00125268,0.2129183,0.0004069258],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943875,0.0005218678,0.0002334337,0.003092826,0.0002765023,0.0003278822,0.0001298811,0.00001596298,0.001014153],"genre_scores_gemma":[0.9944807,0.00000510703,0.0001491048,0.001147954,0.0001058744,0.0002172598,0.0002555564,0.00002357926,0.00361492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7436252,"threshold_uncertainty_score":0.9998451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993778514551491,"score_gpt":0.301131122844446,"score_spread":0.2811933376989311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}