{"id":"W4294659898","doi":"10.1093/brain/awac315","title":"Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Institut Universitaire de Gériatrie de Montréal","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. National Library of Medicine; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; Canada First Research Excellence Fund; National Institute of Dental and Craniofacial Research; Centre Hospitalier Universitaire Vaudois; Simons Foundation; Health and Care Research Wales; Courtois Foundation; Wellcome Trust; National Institute on Drug Abuse; Institut de Valorisation des Données; Fondation Brain Canada; Canadian Institutes of Health Research; Compute Canada","keywords":"Functional connectivity; Pleiotropy; Neuroscience; Psychology; Psychiatry; Genetics; Biology; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005991694,0.0003595133,0.0004707059,0.001185729,0.0004093596,0.0005520465,0.0001998204,0.0003551944,0.002186404],"category_scores_gemma":[0.003330065,0.0003085542,0.0005441943,0.0009244002,0.0005790347,0.0003652575,0.0008585909,0.0004919851,0.0001341825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915427,"about_ca_system_score_gemma":0.0001886556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002139107,"about_ca_topic_score_gemma":0.004078603,"domain_scores_codex":[0.999196,0.0001937067,0.00007094528,0.0003392868,0.0001069622,0.00009307011],"domain_scores_gemma":[0.998322,0.0006651693,0.0005266554,0.0002688055,0.00007877216,0.0001386977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001376815,0.00008213647,0.8786298,0.0000836176,0.00146412,0.001569479,0.000666398,0.002499177,0.1018903,0.000781149,0.0003752237,0.01058191],"study_design_scores_gemma":[0.000004949913,0.00002617645,0.9979348,0.000002772849,0.00003789394,0.0003343219,0.00003320428,0.0007373071,0.0005201151,0.0003216126,0.00004141489,0.000005463463],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987003,0.00004947829,0.0006733249,0.00003076836,0.000001866741,0.000003614857,0.0002827342,0.000009972909,0.0002480215],"genre_scores_gemma":[0.9991208,0.00002566059,0.0003662345,0.000008692004,0.000004730978,0.000005953423,0.0004135115,0.000008044111,0.00004632612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002186404,"threshold_uncertainty_score":0.007314324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993778514551491,"score_gpt":0.301131122844446,"score_spread":0.2811933376989311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}