{"id":"W4294666970","doi":"10.1021/acs.jmedchem.2c00786","title":"From a Cone Snail Toxin to a Competitive MC4R Antagonist","year":2022,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"FP7 Health; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Université de Paris; Canada Research Chairs","keywords":"Chemistry; Melanocortin 4 receptor; Antagonist; Energy homeostasis; Peptide; Conotoxin; Venom; Melanocortin; Endogeny; Receptor; Competitive antagonist; Pharmacology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502151,0.0002842723,0.000192735,0.0001778833,0.0001418728,0.0001951604,0.0002699726,0.0002755803,0.003006922],"category_scores_gemma":[0.0001329492,0.0001238318,0.0002238985,0.0001121478,0.0002082606,0.0001197094,0.0001950172,0.0005274889,0.0007763869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002959763,"about_ca_system_score_gemma":0.0003172697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006615792,"about_ca_topic_score_gemma":0.0009674365,"domain_scores_codex":[0.9998914,0.00002371953,0.000006913291,0.00002098184,0.00002784303,0.00002905313],"domain_scores_gemma":[0.9999561,0.000009295204,0.000009056789,0.000004342049,0.000007529439,0.00001362132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001755345,0.00006703105,0.0001365851,0.00006771417,0.00001051894,0.00009852774,0.00001708476,0.0001250794,0.99582,0.0003470708,0.0001800583,0.002954686],"study_design_scores_gemma":[0.0001668948,0.00238609,0.002502158,0.00002563091,0.00003689504,0.001103285,0.00002488492,0.00224142,0.9748455,0.0001560752,0.0164975,0.00001376596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728483,0.004672957,0.009989664,0.0005333979,0.0001563923,0.0003207279,0.0005006227,0.0001609134,0.01081695],"genre_scores_gemma":[0.9758356,0.002673061,0.009302873,0.0005215702,0.00004180446,0.0001030386,0.0007632342,0.0000229167,0.01073584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003006922,"threshold_uncertainty_score":0.01005918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007695989031028493,"score_gpt":0.2431344929712628,"score_spread":0.2354385039402343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}