{"id":"W4294671633","doi":"10.1016/j.jconrel.2022.08.058","title":"Hepatocyte-targeted delivery of imiquimod reduces hepatitis B virus surface antigen","year":2022,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"NanoMedicines Innovation Network; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"HBsAg; Hepatitis B virus; In vivo; HBcAg; Hepatocyte; Pharmacokinetics; Pharmacology; Imiquimod; Chemistry; Drug; Hepatitis B; In vitro; Virology; Immunology; Virus; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001052982,0.000252949,0.001703924,0.0003290238,0.0002579957,0.00001478209,0.0002494788,0.00007399759,0.0008031944],"category_scores_gemma":[0.0008624392,0.0002075713,0.0007179076,0.000375233,0.0001240514,0.0001587885,0.0001351421,0.0006439236,0.00001073345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724233,"about_ca_system_score_gemma":0.0008249473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001613199,"about_ca_topic_score_gemma":0.0001756768,"domain_scores_codex":[0.9964053,0.0004676892,0.001465932,0.0002032657,0.001101954,0.0003558343],"domain_scores_gemma":[0.9967533,0.0003849049,0.001387523,0.0002806475,0.0009160836,0.0002774944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.04163606,0.002104298,0.3279141,0.0001545143,0.004546728,0.003478978,0.00171404,0.002229529,0.5904267,0.00008297811,0.02002358,0.005688476],"study_design_scores_gemma":[0.2238509,0.0270347,0.3587959,0.001411146,0.006594624,0.004300299,0.002144882,0.0179723,0.2866184,0.0008986106,0.0681833,0.002194847],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980435,0.01635599,0.00008487211,0.001127057,0.0006268086,0.0006484741,0.0000852156,0.00002476224,0.0006118607],"genre_scores_gemma":[0.9889697,0.009030931,0.0007849477,0.0004774792,0.0002363473,0.00001796222,0.000005903771,0.00004136247,0.0004353995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3038083,"threshold_uncertainty_score":0.8794416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132535367686485,"score_gpt":0.2556935002251053,"score_spread":0.2424399634564569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}