{"id":"W4294719133","doi":"10.1002/prp2.995","title":"Correlation of functional and radioligand binding characteristics of <scp>GPER</scp> ligands confirming aldosterone as a <scp>GPER</scp> agonist","year":2022,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Robarts Clinical Trials","funders":"Heart and Stroke Foundation of Canada","keywords":"GPER; Aldosterone; Receptor; Agonist; Mineralocorticoid receptor; Mineralocorticoid; Endocrinology; Biology; Chemistry; Internal medicine; Estrogen receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004440562,0.0008005914,0.0006977102,0.0006889915,0.0003454305,0.0005595152,0.0004372796,0.0006179794,0.006838004],"category_scores_gemma":[0.000652025,0.0002559088,0.0004600791,0.0004597554,0.0003568036,0.0002784042,0.000260482,0.0008065054,0.003679675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007257066,"about_ca_system_score_gemma":0.0003124978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002118617,"about_ca_topic_score_gemma":0.002955259,"domain_scores_codex":[0.999202,0.0001731251,0.00004939449,0.0001251252,0.0002617326,0.0001887294],"domain_scores_gemma":[0.9993332,0.0002430041,0.00003960651,0.00006948541,0.0001603639,0.0001544235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000069226,0.00002312544,0.0001196476,0.00002915056,0.000009406456,0.00004926581,0.00001073274,0.00005653171,0.9986749,0.00006899328,0.00007826518,0.0008108783],"study_design_scores_gemma":[0.00001818587,0.0004603474,0.01031169,0.00001247537,0.00002482276,0.000860146,0.00006130612,0.001446411,0.9827103,0.00006406867,0.004011129,0.00001907037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647468,0.004180583,0.01525842,0.0004172889,0.00008714363,0.0001812549,0.00195196,0.0003263254,0.01285019],"genre_scores_gemma":[0.9643138,0.00171763,0.01175502,0.0004036528,0.00005877161,0.0002018977,0.005135771,0.0002278317,0.01618569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006838004,"threshold_uncertainty_score":0.02287537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266931933385348,"score_gpt":0.326838269372804,"score_spread":0.3041689500389505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}