{"id":"W4294719133","doi":"10.1002/prp2.995","title":"Correlation of functional and radioligand binding characteristics of <scp>GPER</scp> ligands confirming aldosterone as a <scp>GPER</scp> agonist","year":2022,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Robarts Clinical Trials","funders":"Heart and Stroke Foundation of Canada","keywords":"GPER; Aldosterone; Receptor; Agonist; Mineralocorticoid receptor; Mineralocorticoid; Endocrinology; Biology; Chemistry; Internal medicine; Estrogen receptor; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001224729,0.0002360653,0.0003926421,0.0003609324,0.000636286,0.00002966676,0.0002524337,0.0002242347,0.00006914308],"category_scores_gemma":[0.0006437473,0.0002438479,0.0001234595,0.0003882469,0.0008693118,0.00002008668,0.0004867211,0.0008537328,0.000008568977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009954986,"about_ca_system_score_gemma":0.0003408121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003803557,"about_ca_topic_score_gemma":0.000001324908,"domain_scores_codex":[0.9974725,0.0005148135,0.0003750606,0.0005928192,0.0004753277,0.0005694852],"domain_scores_gemma":[0.9983304,0.0006174408,0.0002465068,0.000205576,0.0004051368,0.0001950068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002282396,0.0003564278,0.00857196,0.00006926596,0.0005263397,0.00003439902,0.003711969,0.0001118305,0.9805003,0.0002921996,0.005346282,0.0002508131],"study_design_scores_gemma":[0.003200871,0.003295935,0.01081183,0.00003308147,0.0001822694,0.0003573286,0.01677689,0.001134605,0.9526751,0.00008390628,0.01133405,0.0001141419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901135,0.006993454,0.00005900849,0.0001534365,0.0003622787,0.0005357678,0.000110418,0.00001797728,0.001654134],"genre_scores_gemma":[0.9948757,0.001942665,0.00003922497,0.00004568997,0.0003010743,0.0001214458,0.0001979953,0.00004069726,0.002435497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02782518,"threshold_uncertainty_score":0.994383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266931933385348,"score_gpt":0.326838269372804,"score_spread":0.3041689500389505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}