{"id":"W4294733313","doi":"10.3390/ijms231710157","title":"Transcriptome-Wide Detection of Intron/Exon Definition in the Endogenous Pre-mRNA Transcripts of Mammalian Cells and Its Regulation by Depolarization","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Génome Québec; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Intron; Transcriptome; Endogeny; Exon; Depolarization; Messenger RNA; Biology; Computational biology; Cell biology; Gene expression; Genetics; Gene; Biophysics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244459,0.0001307935,0.000267713,0.000171646,0.0001991958,0.0004011356,0.0001057519,0.0001708972,0.0007070825],"category_scores_gemma":[0.0001751432,0.0001279317,0.0002294216,0.0002415769,0.0002028154,0.0001979895,0.000274945,0.0004033068,0.0002848303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000141296,"about_ca_system_score_gemma":0.0001625883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003036466,"about_ca_topic_score_gemma":0.0007208494,"domain_scores_codex":[0.9998066,0.00001444606,0.0000125072,0.00008732975,0.00005439701,0.00002480405],"domain_scores_gemma":[0.9998813,0.00002444707,0.00003246916,0.0000146866,0.00002631562,0.00002087606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005691871,0.000005747023,0.002665538,0.00003282743,0.000006802154,0.00002971628,0.00004665024,0.0000508837,0.9953753,0.00008983216,0.00003044229,0.001609329],"study_design_scores_gemma":[0.00001101478,0.0001690397,0.3631963,0.00002199679,0.00005896935,0.0004969038,0.0002635873,0.002865057,0.6282514,0.0003611949,0.00428345,0.0000211484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851093,0.001391458,0.01010546,0.00004386847,0.00002653991,0.00002257791,0.001494349,0.000105093,0.001701321],"genre_scores_gemma":[0.9907554,0.0005570492,0.004427651,0.00009353161,0.00001156296,0.00004965072,0.002677945,0.00004207297,0.001385124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007070825,"threshold_uncertainty_score":0.00236547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808303224365283,"score_gpt":0.2512550710423352,"score_spread":0.2331720387986824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}