{"id":"W4294762973","doi":"10.1007/s00401-022-02454-z","title":"Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers","year":2022,"lang":"en","type":"review","venue":"Acta Neuropathologica","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University of Toronto; University Health Network","funders":"National Institute on Aging; National Institutes of Health; Fondation pour la Recherche sur Alzheimer; Julius Clinical; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Servier; Instituto de Salud Carlos III; Siemens Healthineers; Stichting Dioraphte; Hersenstichting; Universiteit Antwerpen; Oryzon Genomics; Vetenskapsrådet; Eisai; Fonds Wetenschappelijk Onderzoek; Novo Nordisk; European Regional Development Fund; Bundesministerium für Bildung und Forschung; Academy of Finland; Amsterdam Neuroscience; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Grifols; Agence Nationale de la Recherche; H. Lundbeck A/S; Sunovion; Deutsches Zentrum für Neurodegenerative Erkrankungen; Deutsche Forschungsgemeinschaft; European Federation of Pharmaceutical Industries and Associations; EU Joint Programme – Neurodegenerative Disease Research; Danone; European Commission; Vlaamse regering; Esteve Pharmaceuticals; Alzheimer Nederland; Pfizer; Biogen; Health~Holland; Hope Center for Neurological Disorders; Eli Lilly and Company","keywords":"Cerebrospinal fluid; Biobank; Pathogenesis; Etiology; Alzheimer's disease; Locus (genetics); Genome-wide association study; Dementia; Disease; Biology; Apolipoprotein E; Medicine; Pathology; Bioinformatics; Genetics; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004526755,0.002173316,0.008448563,0.002733034,0.0002713693,0.001471325,0.00135106,0.001256198,0.003247118],"category_scores_gemma":[0.00772696,0.0006307777,0.01725953,0.004193649,0.0002352719,0.0007036281,0.0008616741,0.001514401,0.000346945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009341585,"about_ca_system_score_gemma":0.001370578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003316739,"about_ca_topic_score_gemma":0.006422045,"domain_scores_codex":[0.9978189,0.001143093,0.000298605,0.0004072417,0.0002237116,0.0001084404],"domain_scores_gemma":[0.995715,0.003408935,0.0003121392,0.0001902035,0.0002902072,0.00008352786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00395235,0.00005400833,0.0109995,0.1389109,0.7130305,0.0002818957,0.00005871271,0.001983854,0.0007886206,0.0005880778,0.005806149,0.1235454],"study_design_scores_gemma":[0.0008304737,0.0003169159,0.0219849,0.01110372,0.9500011,0.0004212366,0.00004432748,0.0009232406,0.0005140699,0.001305542,0.01249691,0.00005770554],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001964923,0.9968466,0.0003991466,0.0001848482,0.0001164039,0.00001714545,0.0002883594,0.00002178512,0.000160746],"genre_scores_gemma":[0.08003207,0.91636,0.001263268,0.0004597337,0.0003211655,0.0001122704,0.001130148,0.00003259442,0.0002886633],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008448563,"threshold_uncertainty_score":0.02394003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2629827493489242,"score_gpt":0.3968662580193351,"score_spread":0.1338835086704108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}