{"id":"W4294768231","doi":"10.1101/2022.09.02.506110","title":"Developmental Basis of SHH Medulloblastoma Heterogeneity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Hospital for Sick Children; Terry Fox Research Institute; Brain Tumour Charity; Stand Up To Cancer; Genome British Columbia; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Government of Ontario; Cancer Research UK; Ontario Institute for Cancer Research; University of Toronto; USC Norris Comprehensive Cancer Center; Genome Canada","keywords":"Sonic hedgehog; Medulloblastoma; Biology; Cell of origin; Progenitor cell; Granule cell; Cell type; Cellular differentiation; Stem cell; Cell; Pathology; Cancer research; Neuroscience; Cell biology; Genetics; Central nervous system; Gene; Medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003562934,0.0001666739,0.0002367165,0.0006874939,0.0002048715,0.0007046594,0.0002821946,0.0001706808,0.001005335],"category_scores_gemma":[0.0009200305,0.0002070164,0.0003221357,0.0006431442,0.000383159,0.0003111743,0.0004090861,0.0002338168,0.0001712914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004539062,"about_ca_system_score_gemma":0.0002443455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002599753,"about_ca_topic_score_gemma":0.00361405,"domain_scores_codex":[0.9997715,0.00003267597,0.00001523293,0.0001065118,0.00004931902,0.0000247205],"domain_scores_gemma":[0.9996469,0.0001704164,0.00007396727,0.00004572048,0.00003654358,0.00002631568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004830119,0.00003934339,0.2781307,0.0003426847,0.0003241524,0.0005607302,0.0004399011,0.07182397,0.6086807,0.01405644,0.001376035,0.02374234],"study_design_scores_gemma":[0.00003135005,0.00008169992,0.5302928,0.00003866665,0.0002020083,0.0006384149,0.0004135156,0.289156,0.1509551,0.02064388,0.0074769,0.00006961344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806936,0.0002006515,0.01465683,0.0000488093,0.000004372841,0.000008968193,0.00295162,0.0003114563,0.001123733],"genre_scores_gemma":[0.9937531,0.00007479625,0.003642614,0.000008781283,0.000002969886,0.000008276975,0.002303736,0.00007161653,0.000134054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002599753,"threshold_uncertainty_score":0.005169272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008745843903538648,"score_gpt":0.2089227001395702,"score_spread":0.2001768562360316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}