{"id":"W4294771021","doi":"10.1158/2643-3249.lymphoma22-a12","title":"Abstract A12: Pervasive hypermutation of super-enhancer regions dysregulates oncogene expression in diffuse large B-cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Somatic hypermutation; Enhancer; Genetics; Gene; Cancer research; Germinal center; B cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009827584,0.0002213136,0.0004177448,0.0001579794,0.0001372332,0.0000209381,0.0001145998,0.00006575184,0.0003360909],"category_scores_gemma":[0.00001531314,0.0001907504,0.000192901,0.0002780449,0.00004415694,0.0002529522,0.0001250847,0.00008773283,0.000006451843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004760347,"about_ca_system_score_gemma":0.0004654878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008315486,"about_ca_topic_score_gemma":0.0002420039,"domain_scores_codex":[0.9983485,0.00005403984,0.0003936769,0.0004195155,0.0004572307,0.0003269959],"domain_scores_gemma":[0.9992058,0.00009544473,0.0001844416,0.0003690479,0.0000529641,0.00009224888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001546385,0.07944908,0.3312343,0.0006840273,0.0005088142,0.0008798325,0.004714626,0.0005603964,0.569994,0.0003195925,0.003451652,0.006657308],"study_design_scores_gemma":[0.03632691,0.000452517,0.3373397,0.0004192802,0.0004125886,0.00003980805,0.001919574,0.00003547087,0.6208299,0.0001026695,0.00184632,0.0002752065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884214,0.00911673,0.000005288,0.0004805262,0.0002074457,0.0005128223,0.0004098089,0.0000265694,0.0008193987],"genre_scores_gemma":[0.9960436,0.001727189,0.00006085945,0.0002381717,0.0001013311,0.0008053177,0.0002205792,0.00003806232,0.0007648712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07899657,"threshold_uncertainty_score":0.7778576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012631251303587,"score_gpt":0.2578647238791112,"score_spread":0.2452334725755242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}