{"id":"W4294771021","doi":"10.1158/2643-3249.lymphoma22-a12","title":"Abstract A12: Pervasive hypermutation of super-enhancer regions dysregulates oncogene expression in diffuse large B-cell lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Biology; Diffuse large B-cell lymphoma; Somatic hypermutation; Enhancer; Genetics; Gene; Cancer research; Germinal center; B cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009281513,0.0002047824,0.0001785205,0.0003259345,0.000111777,0.0002981693,0.0001010584,0.0001634524,0.002293569],"category_scores_gemma":[0.0001058709,0.0001129486,0.0001670515,0.0002420634,0.0001710805,0.00007152765,0.0001924426,0.0003471549,0.0005462114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663088,"about_ca_system_score_gemma":0.0001052096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005526461,"about_ca_topic_score_gemma":0.0007559233,"domain_scores_codex":[0.9998341,0.00002189768,0.00001232484,0.00004676555,0.0000522853,0.00003263],"domain_scores_gemma":[0.9998707,0.00002276847,0.00003626516,0.00001677014,0.0000119513,0.00004159797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007317315,0.0000151239,0.001201569,0.00001505872,0.000005279834,0.00005505409,0.000008422889,0.00002598716,0.9976903,0.00002337769,0.00003246751,0.0008542266],"study_design_scores_gemma":[0.00003738936,0.0005651159,0.139199,0.0000107113,0.00005252924,0.002029181,0.0001289787,0.001639083,0.8515158,0.0001027152,0.004709962,0.000009668532],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9969679,0.0005244045,0.001245034,0.00002938454,0.000009223956,0.000009817408,0.0005053343,0.0001033087,0.0006055834],"genre_scores_gemma":[0.997983,0.0001451099,0.0003897462,0.00002400242,0.000003086976,0.00001076181,0.0005326433,0.00002251786,0.0008891429],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002293569,"threshold_uncertainty_score":0.007672727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012631251303587,"score_gpt":0.2578647238791112,"score_spread":0.2452334725755242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}