{"id":"W4294775244","doi":"10.1158/2643-3249.lymphoma22-a24","title":"Abstract A24: <i>BTG1</i> mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Biology; Germinal center; Lymphoma; Cancer research; Mutation; B cell; Immunology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009348246,0.0001568194,0.0001087277,0.00002763524,0.0003886685,0.00006272696,0.00012149,0.00006905299,0.00001810945],"category_scores_gemma":[0.000007090649,0.0001414982,0.00005545629,0.0000816376,0.00006324773,0.00002237796,0.0001264952,0.00007628825,3.941699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008495251,"about_ca_system_score_gemma":0.0003189534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004857027,"about_ca_topic_score_gemma":0.00009438522,"domain_scores_codex":[0.99905,0.0000154809,0.0001965452,0.0003663614,0.0001630559,0.0002085138],"domain_scores_gemma":[0.9994955,0.00001118284,0.0002144426,0.0001946607,0.00004573925,0.00003845401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002521521,0.0002465921,0.0005543957,0.00009588161,0.0002111527,0.000002883681,0.0005543795,0.004430333,0.9769877,0.00001819105,0.002218736,0.01442756],"study_design_scores_gemma":[0.002298773,0.0001486841,0.002007675,0.0000389712,0.0001134858,0.00002879337,0.0005914827,0.00008002676,0.9519942,0.00005885373,0.04233089,0.0003081457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989974,0.00787431,0.0005172706,0.0002200589,0.0003474602,0.0006269253,0.0003045456,0.00001198158,0.0001235117],"genre_scores_gemma":[0.9968296,0.000369609,0.00005913624,0.0001116928,0.0001679339,0.0009844914,0.0005313017,0.00003320209,0.0009129908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04011216,"threshold_uncertainty_score":0.577013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00733294582110307,"score_gpt":0.2367027978724541,"score_spread":0.229369852051351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}