{"id":"W4294775244","doi":"10.1158/2643-3249.lymphoma22-a24","title":"Abstract A24: <i>BTG1</i> mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction","year":2022,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"","keywords":"Diffuse large B-cell lymphoma; Biology; Germinal center; Lymphoma; Cancer research; Mutation; B cell; Immunology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126104,0.0003052628,0.0001974806,0.0003510922,0.0001574229,0.0003086637,0.000176749,0.0002907354,0.005047821],"category_scores_gemma":[0.0001161231,0.00008874695,0.0002447092,0.0002241324,0.0002485591,0.0001106359,0.0002107146,0.0005587901,0.0006518715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003118288,"about_ca_system_score_gemma":0.0001420328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320908,"about_ca_topic_score_gemma":0.001238219,"domain_scores_codex":[0.9998479,0.00001914059,0.00001104506,0.00004243909,0.00004103782,0.00003846904],"domain_scores_gemma":[0.9998723,0.00001372786,0.00004390436,0.00001040142,0.00000891745,0.00005075608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002327608,0.00003509323,0.002519512,0.00001862902,0.00001485285,0.00008439489,0.00000967503,0.00008230217,0.9953695,0.00008990217,0.0001776149,0.001365687],"study_design_scores_gemma":[0.00008503498,0.001272938,0.1627281,0.00001730116,0.00009296391,0.003104931,0.0001139117,0.002438385,0.821322,0.0003352574,0.008472715,0.00001647567],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9965714,0.0002758705,0.0009198096,0.0001092979,0.00001598104,0.00001327263,0.001204924,0.0001038389,0.0007854743],"genre_scores_gemma":[0.9971914,0.00008998567,0.0004153267,0.00006648504,0.000006197617,0.00001214982,0.0008075262,0.00003914833,0.001371757],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005047821,"threshold_uncertainty_score":0.01688665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00733294582110307,"score_gpt":0.2367027978724541,"score_spread":0.229369852051351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}