{"id":"W4294782877","doi":"10.1016/j.molcel.2022.08.015","title":"An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research","keywords":"Biology; Ribozyme; RNA; Ribonuclease; ADP-ribosylation; Microbiology; Transfer RNA; Secretion; Cell biology; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002634362,0.0003579519,0.0003788748,0.0001280777,0.0005424079,0.00006600926,0.00062554,0.000233773,0.003918064],"category_scores_gemma":[0.000006338333,0.0003891607,0.0001953305,0.0001760948,0.0000682223,0.0001257559,0.0001740341,0.0006674334,0.0001021601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009669619,"about_ca_system_score_gemma":0.00007340193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304009,"about_ca_topic_score_gemma":0.000004197763,"domain_scores_codex":[0.9977767,0.0004314307,0.0003793356,0.0006226163,0.0001103316,0.0006795997],"domain_scores_gemma":[0.9991339,0.00002843691,0.0001130603,0.0006259605,0.00003010515,0.00006857826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001685889,0.0002364607,0.000004369959,0.00001580328,0.0000646949,0.00005884313,0.0005684342,0.0002696248,0.995407,0.0001309825,0.001756482,0.00131868],"study_design_scores_gemma":[0.002176276,0.0005174363,0.00001334487,0.000006178997,0.00004951793,0.0000228607,0.0003330698,0.00006265911,0.9428583,0.00008458825,0.05343132,0.0004444391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696215,0.0008198668,0.02522001,0.00005471886,0.002569682,0.000517442,0.0004773504,0.0001832812,0.0005361061],"genre_scores_gemma":[0.9968783,0.0000308625,0.0006003879,0.0005673391,0.00003631305,0.00007109984,0.0008265244,0.0001070059,0.0008821417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05254872,"threshold_uncertainty_score":0.9998561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004515751041375376,"score_gpt":0.198290453769792,"score_spread":0.1937747027284166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}