{"id":"W4294782877","doi":"10.1016/j.molcel.2022.08.015","title":"An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Canadian Institutes of Health Research","keywords":"Biology; Ribozyme; RNA; Ribonuclease; ADP-ribosylation; Microbiology; Transfer RNA; Secretion; Cell biology; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637863,0.0003355849,0.0001598807,0.0001812765,0.0001560429,0.0002780657,0.0001654245,0.0003995981,0.0006226891],"category_scores_gemma":[0.0001669835,0.0001413302,0.0002584474,0.0001074384,0.0002624552,0.0001829712,0.0001839534,0.0005052061,0.0003549689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889721,"about_ca_system_score_gemma":0.0001285295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001960839,"about_ca_topic_score_gemma":0.0003392898,"domain_scores_codex":[0.9998783,0.00002772,0.000005615136,0.00002542396,0.00003387766,0.00002915583],"domain_scores_gemma":[0.9998507,0.00004772157,0.00003959974,0.00002244288,0.00001501923,0.00002441471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000322818,0.000008087948,0.00009714906,0.000009983302,0.000002523852,0.00003525351,0.000006674661,0.0001019874,0.9986376,0.0002087852,0.00001633471,0.0008434076],"study_design_scores_gemma":[0.000004951532,0.0001981906,0.001561441,0.000002331651,0.000006225325,0.0001370037,0.00001098399,0.001191294,0.9959108,0.000143511,0.000830917,0.00000252988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759812,0.001350205,0.01969052,0.0001451198,0.0000505936,0.00003331971,0.00009332132,0.0001278262,0.002527952],"genre_scores_gemma":[0.9919016,0.0004777022,0.004719743,0.00006964477,0.00001431749,0.00001575447,0.0001292593,0.00001925509,0.002652815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006226891,"threshold_uncertainty_score":0.002096713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004515751041375376,"score_gpt":0.198290453769792,"score_spread":0.1937747027284166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}